Results 21 to 30 of about 233,309 (305)

Homologous recombination proficiency in ovarian and breast cancer patients

BMC Cancer, 2021
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden, Nisha S. Nanavaty, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae M. Hamouda, Lance Dworkin, John Nemunaitis   +7 more
doaj   +1 more source

Homologous Recombination Assay

Bio-Protocol, 2013
Repair of double strand break by homologous recombination was examined using U2OS cells or RG37 cells harbouring specific substrate developed by Puget et al. (2005) and Dumay et al.
Yvan Canitrot, Didier Trouche
doaj   +1 more source

Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]

, 2014
With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves, Verge, Valerie, Carré, Isabelle A., Schatt, Philippe, Botebol, Hugo, Blain, Stephane, Lozano, Jean-Claude, Lesuisse, Emmanuel, Carré, Isabelle A   +8 more
core   +1 more source

Isolation and characterization of "Arabidopsis" mutants with altered homologous recombination levels : a new function for an INO80 SWI/SNF ATPase [PDF]

, 2006
Homologous recombination (HR) in eukaryotic organisms serves a dual role in providing genetic flexibility by creating novel sequence assortments upon meiosis and in maintaining genome integrity through DNA repair in somatic tissues.
Fritsch, Olivier
core   +1 more source

ASYNAPSIS 1 ensures crossover fidelity in polyploid wheat by promoting homologous recombination and suppressing non-homologous recombination [PDF]

, 2023
During meiosis, the chromosome axes and synaptonemal complex mediate chromosome pairing and homologous recombination to maintain genomic stability and accurate chromosome segregation.
Sourdille, Pierre, Pierre Sourdille, Chiara Di Dio, Heïdi Serra, Serra, Heïdi, James D. Higgins, Di Dio, Chiara, Higgins, James, D   +7 more
core   +1 more source

Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery

Biomolecules, 2012
Homologous recombination is a universal mechanism that allows DNA repair and ensures the efficiency of DNA replication. The substrate initiating the process of homologous recombination is a single-stranded DNA that promotes a strand exchange reaction ...
Audrey Costes, Sarah A. E. Lambert
doaj   +1 more source

Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]

, 2006
The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC, Savitzky, MH, Sunjevaric, [No Value], Rothstein, R, Marrero, VA, Thorpe, PH   +5 more
core   +1 more source

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Clinics, 2018
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio, Rodrigo Nogueira Fogace, Vanessa Costa Miranda, Maria del Pilar Estevez Diz   +3 more
doaj   +1 more source

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Dal Peraro, Matteo, Dal Peraro, M., Kalantzi, Alexandra-Styliani, Toseland, Christopher P., Oh, B., Shin, H.-C., Oh, Byung-Ha, M D Peraro, A S Kalantzi, Toseland, C.P., Shin, Ho-Chul, S Gruber, Kalantzi, A., Kang, H.-A., Kang, H., Toseland, C., Ho-Chul Shin, Gruber, Stephan, Kalantzi, A.-S., Oh, B.-H., Kim, H.-M., H A Kang, B H Oh, Kang, Hyun-Ah, Kim, Hyun-Min, Gruber, S., H M Kim, Shin, H., C P Toseland, Kim, H.   +29 more
core   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255), Copsey A., Prakash Arumugam, Sonya Newcombe (502072), Jordan, Philip W., Gray S., Alice Copsey (4460686), Alex D Herbert, Eva Hoffmann (159398), Li, Zhaobo, Shangming Tang, Zhaobo Li, Stephen Gray, Newnham, Louise, Herbert A.D., Chan, Andrew Chi-ho, Hannah G. Blitzblau (159462), Blitzblau, Hannah G., Gray, Stephen, Alex Herbert (725932), Hannah G Blitzblau, Hannah Blitzblau (5185454), Newcombe S., Tang, Shangming, Stephen Gray (3278418), Newnham L., Li Z., Hunter, Neil, Andrew Chi-ho Chan (3278421), Hochwagen, Andreas, Arumugam, Prakash, Shangming Tang (502071), Hochwagen A., Alice Copsey, Alice Copsey (502070), Copsey, Alice, Herbert, Alex D., Hoffmann E., Blitzblau H.G., Andreas Hochwagen (159466), Arumugam P., Louise Newnham, Neil Hunter, Philip W Jordan (16188074), Jordan P.W., Alex D. Herbert (502074), Philip W Jordan, Andrew Chi-Ho Chan, Louise Newnham (430862), Sonya Newcombe, Chan, Andrew Chi ho, Tang S., Prakash Arumugam (303310), Eva Hoffmann, Newcombe, Sonya, Andreas Hochwagen, Hunter N., Chan A.C.-h., Neil Hunter (155061), Steve Gray (5950955), Zhaobo Li (502073), Hoffmann, Eva   +61 more
core   +1 more source