Homologous recombination proficiency in ovarian and breast cancer patients
BMC Cancer, 2021 Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden +7 more
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Homologous Recombination: Down to the Wire [PDF]
Current Biology, 2004 Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Wyman, C.L., Kanaar, Roland
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Homologous Recombination Assay
Bio-Protocol, 2013 Repair of double strand break by homologous recombination was examined using U2OS cells or RG37 cells harbouring specific substrate developed by Puget et al. (2005) and Dumay et al.
Yvan Canitrot, Didier Trouche
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Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]
, 2014 With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves +8 more
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Isolation and characterization of "Arabidopsis" mutants with altered homologous recombination levels : a new function for an INO80 SWI/SNF ATPase [PDF]
, 2006 Homologous recombination (HR) in eukaryotic organisms serves a dual role in providing genetic flexibility by creating novel sequence assortments upon meiosis and in maintaining genome integrity through DNA repair in somatic tissues.
Fritsch, Olivier
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Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery
Biomolecules, 2012 Homologous recombination is a universal mechanism that allows DNA repair and ensures the efficiency of DNA replication. The substrate initiating the process of homologous recombination is a single-stranded DNA that promotes a strand exchange reaction ...
Audrey Costes, Sarah A. E. Lambert
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Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]
, 2006 The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC +5 more
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Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]
, 2015 In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Dal Peraro, Matteo +29 more
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Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]
, 2005 In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C +3 more
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A transient assay for recombination demonstrates that Arabidopsis SNM1 and XRCC3 enhance non-homologous recombination [PDF]
, 2011 Replacement of endogenous genes by homologous recombination is rare in plants; the majority of genetic modifications are the result of transforming DNA molecules undergoing random genomic insertion by way of non-homologous recombination.
Hellens, R.P., Johnson, R.A., Love, D.R.
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