Results 11 to 20 of about 510,614 (286)
Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
Clinics, 2018 Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio +3 more
exaly +3 more sources
Recombination: Homologous recombination branches out [PDF]
Current Biology, 2001 Homologous recombination can be divided into three key steps: strand exchange, branch migration and resolution. The identification of a protein complex that catalyses branch migration and Holliday junction resolution argues that the mechanism of ...
Hiom, Kevin, Kevin Hiom
core +4 more sources
Homologous Recombination in Negative Sense RNA Viruses
Viruses, 2011 Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently.
Michael Worobey, Guan-Zhu Han
doaj +2 more sources
Use of a unique reporter cassette to examine 5´ to 3´ resection at a site specific DNA double-strand break during meiosis [PDF]
, 2006 Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand breaks (DSBs), which are created by Spoil protein.
Bishop-Bailey, Anna
core +6 more sources
Homologous recombination risk in baculovirus expression vector system
Virus Research, 2022 The baculovirus expression vector system (BEVS) is widely used for producing recombinant proteins. To achieve high expression level of recombinant proteins, baculoviral elements, such as enhancers, promoters, signal peptide coding sequences and 3′-UTR ...
Jianan Huang, Huanlei Liu, Xiaodong Xu
doaj +1 more source
Multi-scale characterisation of homologous recombination deficiency in breast cancer
Genome Medicine, 2023 Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson +3 more
doaj +1 more source
Genome Biology, 2022 Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals.
Shenli Yuan +7 more
doaj +1 more source
eLife, 2022 Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg +2 more
doaj +1 more source
BRCA2 and homologous recombination [PDF]
Breast Cancer Research, 2001 Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
B J, Orelli, D K, Bishop
openaire +2 more sources
Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. [PDF]
PLoS Genetics, 2016 Replications forks are routinely hindered by different endogenous stresses. Because homologous recombination plays a pivotal role in the reactivation of arrested replication forks, defects in homologous recombination reveal the initial endogenous stress ...
Therese Wilhelm +8 more
doaj +1 more source