Results 11 to 20 of about 233,309 (305)
Recombination: Homologous recombination branches out [PDF]
Current Biology, 2001 Homologous recombination can be divided into three key steps: strand exchange, branch migration and resolution. The identification of a protein complex that catalyses branch migration and Holliday junction resolution argues that the mechanism of homologous recombination is conserved from bacteria to man.
Hiom, Kevin, Kevin Hiom
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The many facets of homologous recombination at telomeres [PDF]
Microbial Cell, 2015 The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctional telomere may resemble a DNA double-strand break (DSB), which is a severe form of DNA damage. The presence of one DSB is sufficient to
Clémence Claussin, Michael Chang
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Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations [PDF]
npj Precision OncologyThis study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes.
Yue Li +3 more
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Homologous recombination risk in baculovirus expression vector system
Virus Research, 2022 The baculovirus expression vector system (BEVS) is widely used for producing recombinant proteins. To achieve high expression level of recombinant proteins, baculoviral elements, such as enhancers, promoters, signal peptide coding sequences and 3′-UTR ...
Jianan Huang, Huanlei Liu, Xiaodong Xu
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Multi-scale characterisation of homologous recombination deficiency in breast cancer
Genome Medicine, 2023 Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson +3 more
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Genome Biology, 2022 Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals.
Shenli Yuan +7 more
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BRCA2 and homologous recombination [PDF]
Breast Cancer Research, 2001 Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
B J, Orelli, D K, Bishop
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eLife, 2022 Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg +2 more
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Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. [PDF]
PLoS Genetics, 2016 Replications forks are routinely hindered by different endogenous stresses. Because homologous recombination plays a pivotal role in the reactivation of arrested replication forks, defects in homologous recombination reveal the initial endogenous stress ...
Therese Wilhelm +8 more
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Homologous Recombination: Down to the Wire [PDF]
Current Biology, 2004 Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Wyman, C.L., Kanaar, Roland
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