Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, EarlyView.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source
Rapid assay for extrachromosomal homologous recombination in monkey cells.
, 1985 Jeffrey E. Rubnitz, Suresh Subramani
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A mitochondrial retroplasmid integrates into mitochondrial DNA by a novel mechanism involving the synthesis of a hybrid cDNA and homologous recombination. [PDF]
, 1994 Chia-Chien Chiang +3 more
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Engineering antibodies with cancer‐associated binding sites
BMEMat, EarlyView.This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian +4 more
wiley +1 more source
Homologous recombination in the tandem calmodulin genes of Trypanosoma brucei yields multiple products: compensation for deleterious deletions by gene amplification. [PDF]
, 1991 Josiane E. Eid, B Sollner-Webb
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Biomarkers for Homologous Recombination Deficiency in Cancer
Journal of the National Cancer Institute, 2018 M. Hoppe +3 more
semanticscholar +1 more source
Pan‐cancer analysis shapes the understanding of cancer biology and medicine
Cancer Communications, EarlyView.Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen +21 more
wiley +1 more source
Homologous recombination catalyzed by a nuclear extract from Xenopus oocytes. [PDF]
, 1991 Chris W. Lehman, Dana Carroll
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Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor
Cancer Communications, EarlyView.Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai +6 more
wiley +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source