Results 201 to 210 of about 789,870 (314)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Daxx-Dependent H3.3 Deposition Promotes Double-Strand Breaks Repair by Homologous Recombination. [PDF]

Cells
Zannini L, Aliprandi S, Delia D, Buscemi G.   +3 more
europepmc   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Homologous Recombination Deficiency and Survival in Ovarian High-Grade Serous Carcinoma by Self-Reported Race. [PDF]

Cancer Epidemiol Biomarkers Prev
Lawson-Michod KA, Johnson CE, Barnard ME, Davidson NR, Collin LJ, Nix DA, Huff CD, Berchuck A, Salas LA, Greene CS, Marks JR, Peres LC, Doherty JA, Schildkraut JM.   +13 more
europepmc   +1 more source

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

Nature Biotechnology, 2013
Jian-Feng Li, J. Norville, John D Aach, M. McCormack, Dandan Zhang, Jenifer Bush, G. Church, J. Sheen   +7 more
semanticscholar   +1 more source

Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection. [PDF]

Nat Commun
Romero-Franco A, Checa-Rodríguez C, Jimeno S, Castellano-Pozo M, Aguilera P, Miras H, Wals A, Jimeno-González S, Lopez-Contreras AJ, Huertas P.   +9 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Defect-complementation homologous recombination: A novel strategy for precise genome engineering of virulent phages. [PDF]

Synth Syst Biotechnol
Zhang H, Song Y, Liu W, Zheng X, An X, Li C, Chen W, Wang H, Zhang Y.   +8 more
europepmc   +1 more source

Cell cycle-dependent control of homologous recombination.

Acta Biochimica et Biophysica Sinica, 2017
Xin Zhao, Chengwen Wei, Jingjing Li, P. Xing, Jingyao Li, Sihao Zheng, Xuefeng Chen   +6 more
semanticscholar   +1 more source