Results 221 to 230 of about 345,396 (332)

Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, EarlyView.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Homologous recombination deficiency in breast cancer: genomic characteristics, clinical implications, and predictive value in neoadjuvant therapy. [PDF]

Front Oncol
Huang J, Luan F, Yan L, Liang X, Ma X, An Y, Hu S, Gao G, Wang Y, Yang J, Dong D.   +10 more
europepmc   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer. [PDF]

NAR Cancer
Gao B, Wang X, Long M, Zhang F, Wang Y, Kumar R, Veillard I, Rueda BR, Yeku O, Lan L.   +9 more
europepmc   +1 more source

Molecular evidence that homologous recombination occurs in proliferating human somatic cells.

, 1990
Joanna Groden, Yusuke Nakamura, J German
openalex   +1 more source

A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr Product [PDF]

, 1997
Andrés Castellanos‐Martín, Belén Pintado, Eduardo Weruaga, R. Arévalo, Andrew Lopez, Alberto Órfão, Isidro Sánchez-Garcı́a   +6 more
openalex   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, EarlyView.
GA: Genetically encoded internal electrophiles in ubiquitin (Ub) enable the profiling of multivalent interaction interfaces, addressing a key limitation of current Ub‐based activity‐based probes. In this study, these probes capture a Ub–deubiquitinase interaction with minimal structural perturbation and serve as selective diUb probes that covalently ...
Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan, Chittaranjan Das   +7 more
wiley   +1 more source

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination. [PDF]

Nat Commun
Deveryshetty J, Mistry A, Pangeni S, Ghoneim M, Tokmina-Lukaszewska M, Gore SK, Liu J, Kaushik V, Karunakaran S, Taddei A, Heyer WD, Ha T, Bothner B, Antony E.   +13 more
europepmc   +1 more source

Efficient homologous recombination of Ty1 element cDNA when integration is blocked.

, 1994
Gil Sharon, Thomas J. Burkett, David Garfinkel   +2 more
openalex   +1 more source

Targeting Cryptochromes in Chronic Diseases

Cell Biology International, EarlyView.
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley   +1 more source