Results 221 to 230 of about 773,827 (377)

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

Advanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou, Rongbin Zhong, Zhonghui Luo, Hua Wei, Cui‐Yun Yu   +4 more
wiley   +1 more source

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment. [PDF]

Curr Issues Mol Biol
Shah B, Hussain M, Seth A.
europepmc   +1 more source

Mechanistic Characterisation of a Diterpene Synthase for Chryseojoostenes A–E from Chryseobacterium Joostei

Angewandte Chemie International Edition, EarlyView.
The bacterial diterpene synthase CjCS for chryseojoostenes was mechanistically characterised through labelling experiments, density functional theory (DFT) calculations, and conversion of substrate analogs with blocked reactivity. Site‐directed mutagenesis gave access to minor enzyme products, including chryseojoostene E, whose biosynthesis involves a ...
Georges B. Tabekoueng, Heng Li, Kexin Yang, Lukas Lauterbach, Bernd Goldfuss, Jeroen S. Dickschat   +5 more
wiley   +1 more source

The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer. [PDF]

Oncologist
Jiang B, Shang Y, Zhang X, He W, Hua H, Ye F, Zhou X, Li Y, Zhong W, Jiang W, Wu G.   +10 more
europepmc   +1 more source

Mutations and homologous recombination induced in mammalian cells by metabolites of benzo[a]pyrene and 1-nitropyrene.

, 1987
Vincent Maher, J D Patton, Jia‐Ling Yang, Y Y Wang, Li Yang, A.E. Aust, Nitai P. Bhattacharyya, J J McCormick   +7 more
openalex   +1 more source

Brca1 and homologous recombination [PDF]

Breast Cancer Research, 1999
openaire   +2 more sources

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source

The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]

, 1992
Paul Hasty, Jaime A. Rivera‐Pérez, Allan Bradley   +2 more
openalex   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, EarlyView.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer. [PDF]

NAR Cancer
Gao B, Wang X, Long M, Zhang F, Wang Y, Kumar R, Veillard I, Rueda BR, Yeku O, Lan L.   +9 more
europepmc   +1 more source