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Multiomics analysis of homologous recombination deficiency across cancer types [PDF]

Biomolecules & Biomedicine
There remains ongoing debate regarding the association of homologous recombination deficiency (HRD) with patient survival across various malignancies, highlighting the need for a comprehensive understanding of HRD's role in different cancer types. Based
Lin Dong, Lin Li, Linyan Zhu, Fei Xu, Rumeng Zhang, Qiushuang Li, Yong Zhu, Zhutian Zeng, Keshuo Ding   +8 more
doaj   +4 more sources

Assessing the association between homologous recombination deficiency scores and treatment response in localized and metastatic prostate cancer [PDF]

The Journal of Pathology: Clinical Research
The aim of this study was to evaluate the predictive value of homologous recombination deficiency scores for therapeutic efficacy in prostate cancer across various disease stages under different regimens.
Qiyu Zhu, Yifu Shi, Ting Wang, Qian Zheng, Xiuya Zhou, Zehua Tan, Junru Chen, Jingjing Guo, Haoyang Liu, Pengfei Shen, Hao Zeng, Jinge Zhao   +11 more
doaj   +2 more sources

Biomarker Assessment of Homologous Recombination Deficiency in Epithelial Ovarian Cancer: Association With Progression-Free Survival After Surgery

Frontiers in Molecular Biosciences, 2022
Identifying BRCA mutations and homologous recombination deficiency (HRD) is the key to choosing patients for poly (ADP-ribose) polymerase inhibitor (PARPi) therapy.
Huan Yi, Linhong Li, Jimiao Huang, Zhiming Ma, Hongping Li, Jian Chen, Xiangqin Zheng, Jingjing Chen, Haixin He, Jianrong Song   +9 more
doaj   +2 more sources

Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations [PDF]

npj Precision Oncology
This study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes.
Yue Li, Xinhua Yang, Haoyang Cai, Fang Wang   +3 more
doaj   +2 more sources

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort [PDF]

BMC Cancer
Background Homologous recombination deficiency (HRD) is associated with sensitivity to platinum-based chemotherapy and PARP inhibitors in BRCA-associated cancers, including ovarian, breast, prostate, and pancreatic cancers.
Lili Ren, Runsi Yao, Ting Hou, Chenglin Liu, Fei Zhao, Xiaojun Chen, Zhou Zhang, Yan Huang   +7 more
doaj   +2 more sources

Breast carcinomas associated with microglandular adenosis are linked to germline alterations in homologous recombination-deficiency genes. [PDF]

NPJ Breast Cancer
Schwartz CJ, Genco I, Repetto M, Muldoon D, Gazzo A, Terraf P, Grabenstetter A, Ross D, Zhang H, Mandelker D, Powell S, Weigelt B, Bandlamudi C, Brogi E, Pareja F, Wen HY.   +15 more
europepmc   +3 more sources

Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer [PDF]

Journal of Ovarian Research
Background The homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi).
Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin   +4 more
doaj   +2 more sources

Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays. [PDF]

J Mol Diagn
Lara Gutierrez A, Halbwedl I, Sauer S, Regitnig P, Petru E, Seeböck R, Schubert S, Peternell C, Bodó K, Prein K, Kashofer K.   +10 more
europepmc   +2 more sources

The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer [PDF]

Zhongguo aizheng zazhi, 2021
Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis ...
YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei
doaj   +1 more source

Multi-scale characterisation of homologous recombination deficiency in breast cancer

Genome Medicine, 2023
Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier   +3 more
doaj   +1 more source