Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]
, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255) +61 more
core +1 more source
Frontiers in Molecular Biosciences, 2022 Identifying BRCA mutations and homologous recombination deficiency (HRD) is the key to choosing patients for poly (ADP-ribose) polymerase inhibitor (PARPi) therapy.
Huan Yi +9 more
doaj +1 more source
Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]
, 2006 The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC +5 more
core +1 more source
The Utility of NGS Analysis in Homologous Recombination Deficiency Tracking
Diagnostics, 2023 Several tumor types have been efficiently treated with PARP inhibitors (PARPis), which are now approved for the treatment of ovarian, breast, prostate, and pancreatic cancers.
Aikaterini Tsantikidi +21 more
doaj +1 more source
Genomic Signature of Homologous Recombination Deficiency in Breast and Ovarian Cancers
Bio-Protocol, 2013 Homologous recombination deficiency, mainly resulted from BRCA1 or BRCA2 inactivation (so called BRCAness), is found in breast and ovarian cancers. Detection of actual inactivation of BRCA1/2 in a tumor is important for patients’ treatment and follow-up ...
Popova Tatiana +2 more
doaj +1 more source
Use of a unique reporter cassette to examine 5´ to 3´ resection at a site specific DNA double-strand break during meiosis [PDF]
, 2006 Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand breaks (DSBs), which are created by Spoil protein.
Bishop-Bailey, Anna
core +6 more sources
Nature Communications, 2020 BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.
Dominik Glodzik +22 more
doaj +1 more source
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]
, 2015 In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Dal Peraro, Matteo +29 more
core +2 more sources
A transient assay for recombination demonstrates that Arabidopsis SNM1 and XRCC3 enhance non-homologous recombination [PDF]
, 2011 Replacement of endogenous genes by homologous recombination is rare in plants; the majority of genetic modifications are the result of transforming DNA molecules undergoing random genomic insertion by way of non-homologous recombination.
Hellens, R.P., Johnson, R.A., Love, D.R.
core +2 more sources
Prediction of homologous recombination deficiency from cancer gene expression data
Journal of International Medical Research, 2022 Objective Homologous recombination deficiency (HRD) is the main mechanism of tumorigenesis in some cancers. HRD causes abnormal double-strand break repair, resulting in genomic scars.
Jun Kang +3 more
doaj +1 more source