Results 21 to 30 of about 52,625 (269)

Multiomics analysis of homologous recombination deficiency across cancer types

Biomolecules & Biomedicine
There remains ongoing debate regarding the association of homologous recombination deficiency (HRD) with patient survival across various malignancies, highlighting the need for a comprehensive understanding of HRD's role in different cancer types. Based
Lin Dong, Lin Li, Linyan Zhu, Fei Xu, Rumeng Zhang, Qiushuang Li, Yong Zhu, Zhutian Zeng, Keshuo Ding   +8 more
doaj   +3 more sources

Homologous Recombination Deficiencies and Hereditary Tumors [PDF]

International Journal of Molecular Sciences, 2021
Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks. Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to inherited susceptibility to specific types of cancers, including those of the breast, ovaries, prostate,
Hideki Yamamoto, Akira Hirasawa
openaire   +3 more sources

The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer [PDF]

Zhongguo aizheng zazhi, 2021
Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis ...
郁　俐, 沈敏娜, 姜惠琴, 王蓓丽, 郭　玮   +4 more
doaj   +2 more sources

Homologous Recombination Deficiency: Concepts, Definitions, and Assays [PDF]

The Oncologist, 2022
AbstractBackgroundHomologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors to poly(adenosine diphosphate [ADP]-ribose) polymerase ...
Mark D Stewart, Diana Merino Vega, Rebecca C Arend, Jonathan F Baden, Olena Barbash, Nike Beaubier, Grace Collins, Tim French, Negar Ghahramani, Patsy Hinson, Petar Jelinic, Matthew J Marton, Kimberly McGregor, Jerod Parsons, Lakshman Ramamurthy, Mark Sausen, Ethan S Sokol, Albrecht Stenzinger, Hillary Stires, Kirsten M Timms, Diana Turco, Iris Wang, J Andrew Williams, Elaine Wong-Ho, Jeff Allen   +24 more
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Determinants of Homologous Recombination Deficiency in Pancreatic Cancer [PDF]

Cancers, 2021
Pancreatic cancer is a treatment-resistant malignancy associated with high mortality. However, defective homologous recombination (HR), a DNA repair mechanism required for high-fidelity repair of double-strand DNA breaks, is a therapeutic vulnerability.
Wattenberg, Max M., Reiss, Kim A.
openaire   +2 more sources

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma [PDF]

, 2023
Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic vulnerabilities and remains poorly ...
Catherine Hagedorn, Herzog, Marius, Hagedorn, Catherine, Domingo Aguilera‐Garcia, Christian Britschgi, Guggenberger, Roman, Bankel, Lorenz, Abdullah Kahraman, Haberecker, Martina, Fabian Arnold, Britschgi, Christian, Pliego-Mendieta, Alicia, Chen, Yanjiang, Moch, Holger, Alicia Pliego‐Mendieta, Chantal Pauli, Arnold, Fabian, Aguilera-Garcia, Domingo, Lorenz Bankel, Mark A Rubin, Sabrina Steiner, Roman Guggenberger, Rubin, Mark A, Martina Haberecker, Zoche, Martin, Marius Herzog, Steiner, Sabrina, Pauli, Chantal, Planas-Paz, Lara, Yanjiang Chen, Kahraman, Abdullah, Lara Planas‐Paz, Martin Zoche, Holger Moch   +33 more
core   +1 more source

Homologous Recombination Deficiency Detection Algorithms: A Systematic Review

Cancers, 2023
Homologous recombination deficiency (HRD) can arise from germline or somatic pathogenic variants as well as other genomic damage and epigenetic alterations in the HR repair pathway. Patients with tumors presenting with an HRD phenotype can show sensitivity to Poly (ADP-ribose) polymerase inhibitors (PARPis).
Lasse Ringsted Mark, Simone Karlsson Terp, Henrik Bygum Krarup, Mads Thomassen, Inge Søkilde Pedersen, Martin Bøgsted   +5 more
openaire   +4 more sources

Homologous recombination deficiency and ovarian cancer [PDF]

European Journal of Cancer, 2016
The discovery that PARP inhibitors block an essential pathway of DNA repair in cells harbouring a BRCA mutation has opened up a new therapeutic avenue for high-grade ovarian cancers. BRCA1 and BRCA2 proteins are essential for high-fidelity repair of double-strand breaks of DNA through the homologous recombination repair (HRR) pathway. Deficiency in HRR
Jonathan A. Ledermann, Yvette Drew, Rebecca S. Kristeleit   +2 more
openaire   +3 more sources

Homologous recombination proficiency in ovarian and breast cancer patients

BMC Cancer, 2021
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden, Nisha S. Nanavaty, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae M. Hamouda, Lance Dworkin, John Nemunaitis   +7 more
doaj   +1 more source

Biomarkers for Homologous Recombination Deficiency in Cancer [PDF]

JNCI: Journal of the National Cancer Institute, 2018
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA repair pathway of clinical interest due to the sensitivity of homologous recombination-deficient cells to poly-ADP ribose polymerase (PARP) inhibitors. The measurement of homologous recombination deficiency (HRD) in cancer is therefore vital to the appropriate design
Michal M, Hoppe, Raghav, Sundar, David S P, Tan, Anand D, Jeyasekharan   +3 more
openaire   +2 more sources