Results 11 to 20 of about 91,698 (296)

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Clinics, 2018
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio, Rodrigo Nogueira Fogace, Vanessa Costa Miranda, Maria del Pilar Estevez Diz   +3 more
doaj   +3 more sources

DirectHRD enables sensitive scar-based classification of homologous recombination deficiency. [PDF]

Nucleic Acids Res
Homologous recombination deficiency (HRD) is a predictive biomarker for efficacy of PARP inhibition and platinum chemotherapy but remains challenging to detect from low tumor fraction samples such as liquid biopsies. Here, we describe DirectHRD, a whole-genome sequencing (WGS) scar-based classifier that is 10x more sensitive than state-of-the-art ...
Liu R, Roberts E, Parsons HA, Stover EH, Choudhury AD, Rhoades J, Blewett T, Yang DD, Liu JF, Mayer EL, Adalsteinsson VA.   +10 more
europepmc   +3 more sources

Homologous Recombination Deficiencies and Hereditary Tumors [PDF]

International Journal of Molecular Sciences, 2021
Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks. Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to inherited susceptibility to specific types of cancers, including those of the breast, ovaries, prostate,
Hideki Yamamoto, Akira Hirasawa
openaire   +3 more sources

Homologous Recombination Deficiency: Concepts, Definitions, and Assays [PDF]

The Oncologist, 2022
AbstractBackgroundHomologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors to poly(adenosine diphosphate [ADP]-ribose) polymerase ...
Mark D Stewart, Diana Merino Vega, Rebecca C Arend, Jonathan F Baden, Olena Barbash, Nike Beaubier, Grace Collins, Tim French, Negar Ghahramani, Patsy Hinson, Petar Jelinic, Matthew J Marton, Kimberly McGregor, Jerod Parsons, Lakshman Ramamurthy, Mark Sausen, Ethan S Sokol, Albrecht Stenzinger, Hillary Stires, Kirsten M Timms, Diana Turco, Iris Wang, J Andrew Williams, Elaine Wong-Ho, Jeff Allen   +24 more
openaire   +2 more sources

Biomarkers for Homologous Recombination Deficiency in Cancer [PDF]

Journal of Personalized Medicine, 2021
DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms can be activated by the cell for DNA repair: the accurate mechanism of homologous recombination repair or the error-prone non-homologous end joining. Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its ...
Wagener-Ryczek, Svenja, Merkelbach-Bruse, Sabine, Siemanowski, Janna   +2 more
openaire   +2 more sources

The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer [PDF]

Zhongguo aizheng zazhi, 2021
Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis ...
YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei
doaj   +1 more source

Homologous Recombination Deficiency Detection Algorithms: A Systematic Review

Cancers, 2023
Homologous recombination deficiency (HRD) can arise from germline or somatic pathogenic variants as well as other genomic damage and epigenetic alterations in the HR repair pathway. Patients with tumors presenting with an HRD phenotype can show sensitivity to Poly (ADP-ribose) polymerase inhibitors (PARPis).
Lasse Ringsted Mark, Simone Karlsson Terp, Henrik Bygum Krarup, Mads Thomassen, Inge Søkilde Pedersen, Martin Bøgsted   +5 more
openaire   +4 more sources

Multi-scale characterisation of homologous recombination deficiency in breast cancer

Genome Medicine, 2023
Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier   +3 more
doaj   +1 more source

Homologous Recombination Deficiency (HRD) in Cutaneous Oncology

International Journal of Molecular Sciences, 2023
Skin cancers, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (SCC), and melanoma, are the most common malignancies in the United States. Loss of DNA repair pathways in the skin plays a significant role in tumorigenesis. In recent years, targeting DNA repair pathways, particularly homologous recombination deficiency (HRD), has ...
Favour A. Akinjiyan, Renee Morecroft, Jordan Phillipps, Tolulope Adeyelu, Andrew Elliott, Soo J. Park, Omar H. Butt, Alice Y. Zhou, George Ansstas   +8 more
openaire   +4 more sources

Determinants of Homologous Recombination Deficiency in Pancreatic Cancer [PDF]

Cancers, 2021
Pancreatic cancer is a treatment-resistant malignancy associated with high mortality. However, defective homologous recombination (HR), a DNA repair mechanism required for high-fidelity repair of double-strand DNA breaks, is a therapeutic vulnerability.
Wattenberg, Max M., Reiss, Kim A.
openaire   +2 more sources