Results 11 to 20 of about 762,366 (142)

Pan-cancer landscape of homologous recombination deficiency [PDF]

Nature Communications, 2020
Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest ...
Luan Nguyen, John W. M. Martens, Arne Van Hoeck, Edwin Cuppen   +3 more
doaj   +3 more sources

Supplementary Data from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response

, 2022
Supplementary Data from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic ...
Hyeon Gu Kang (14956288), Jung Kyoon Choi (9042119), Sinae Kim (245385), Eun Ji Lee (7377419), Eun-Hae Cho (14956297), Haeun Hwangbo (9042110), Byoung-Gie Kim (14956294), Jae-Weon Kim (836885), Suhwan Chang (3939071), Min Ji Park (5540663), Jung-Yun Lee (14956300), Myung Ji Kim (14956291)   +11 more
core   +6 more sources

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma [PDF]

, 2023
Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic vulnerabilities and remains poorly ...
Catherine Hagedorn, Herzog, Marius, Hagedorn, Catherine, Domingo Aguilera‐Garcia, Christian Britschgi, Guggenberger, Roman, Bankel, Lorenz, Abdullah Kahraman, Haberecker, Martina, Fabian Arnold, Britschgi, Christian, Pliego-Mendieta, Alicia, Chen, Yanjiang, Moch, Holger, Alicia Pliego‐Mendieta, Chantal Pauli, Arnold, Fabian, Aguilera-Garcia, Domingo, Lorenz Bankel, Mark A Rubin, Sabrina Steiner, Roman Guggenberger, Rubin, Mark A, Martina Haberecker, Zoche, Martin, Marius Herzog, Steiner, Sabrina, Pauli, Chantal, Planas-Paz, Lara, Yanjiang Chen, Kahraman, Abdullah, Lara Planas‐Paz, Martin Zoche, Holger Moch   +33 more
core   +2 more sources

Targeting homologous recombination deficiency in uterine leiomyosarcoma

Journal of Experimental & Clinical Cancer Research, 2023
Background Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of  0.2) but only two samples had a CHORD score > 50%, one of which had a homozygous pathogenic ...
Genevieve Dall, Cassandra J. Vandenberg, Ksenija Nesic, Gayanie Ratnayake, Wenying Zhu, Joseph H. A. Vissers, Justin Bedő, Jocelyn Penington, Matthew J. Wakefield, Damien Kee, Amandine Carmagnac, Ratana Lim, Kristy Shield-Artin, Briony Milesi, Amanda Lobley, Elizabeth L. Kyran, Emily O’Grady, Joshua Tram, Warren Zhou, Devindee Nugawela, Kym Pham Stewart, Reece Caldwell, Lia Papadopoulos, Ashley P. Ng, Alexander Dobrovic, Stephen B. Fox, Orla McNally, Jeremy D. Power, Tarek Meniawy, Teng Han Tan, Ian M. Collins, Oliver Klein, Stephen Barnett, Inger Olesen, Anne Hamilton, Oliver Hofmann, Sean Grimmond, Anthony T. Papenfuss, Clare L. Scott, Holly E. Barker   +39 more
doaj   +1 more source

Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]

, 2014
With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves, Verge, Valerie, Carré, Isabelle A., Schatt, Philippe, Botebol, Hugo, Blain, Stephane, Lozano, Jean-Claude, Lesuisse, Emmanuel, Carré, Isabelle A   +8 more
core   +1 more source

Isolation and characterization of "Arabidopsis" mutants with altered homologous recombination levels : a new function for an INO80 SWI/SNF ATPase [PDF]

, 2006
Homologous recombination (HR) in eukaryotic organisms serves a dual role in providing genetic flexibility by creating novel sequence assortments upon meiosis and in maintaining genome integrity through DNA repair in somatic tissues.
Fritsch, Olivier
core   +1 more source

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]

, 2005
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C, McCulloch, Richard, Proudfoot, Christopher, McCulloch, R   +3 more
core   +1 more source

DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination

Blood Science, 2021
. Fanconi anemia (FA), an X-linked genetic or autosomal recessive disease, exhibits complicated pathogenesis. Previously, we detected the mutated Dynein Axonemal Heavy Chain 2 (DNAH2) gene in 2 FA cases.
Lixian Chang, Xingjie Gao, Yuxia Wang, Chunmin Huang, Min Gao, Xiaomin Wang, Chao Liu, Wenqi Wu, Wenbin An, Yang Wan, Aoli Zhang, Yingchi Zhang, Weiping Yuan, Xiaofan Zhu   +13 more
doaj   +1 more source

Discovering a qualitative transcriptional signature of homologous recombination defectiveness for prostate cancer

iScience, 2021
Summary: The discovery of homologous recombination deficiency (HRD) biomarkers in prostate cancer is important for patients who will benefit from poly ADP-ribose polymerase inhibitor (PARPi).
Yawei Li, Zhangxiang Zhao, Liqiang Ai, Yuquan Wang, Kaidong Liu, Bo Chen, Tingting Chen, Shuping Zhuang, Huanhuan Xu, Min Zou, Yunyan Gu, Xia Li   +11 more
doaj   +1 more source

DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli. [PDF]

PLoS ONE, 2012
Even a partial loss of function of human RecQ helicase analogs causes adverse effects such as a cancer-prone Werner, Bloom or Rothmund-Thompson syndrome, whereas a complete RecQ deficiency in Escherichia coli is not deleterious for a cell.
Siniša Ivanković, Damir Đermić
doaj   +1 more source