Results 11 to 20 of about 52,625 (269)

Homologous recombination deficiency in pancreatic neuroendocrine tumors. [PDF]

Future Oncol
Aim: Pancreatic Neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms whose tumor biology is still little known. Thanks to next-generation sequencing, pathogenic mutations in base-excision-repair MUTYH gene and homologous recombination genes CHEK2 and BRCA2 seem to have a role in the development of pNETs.Research design & methods: We ...
Bardasi C, Tenedini E, Bonamici L, Benatti S, Bonetti LR, Luppi G, Cortesi L, Tagliafico E, Dominici M, Gelsomino F.   +9 more
europepmc   +6 more sources

Biomarkers for Homologous Recombination Deficiency in Cancer [PDF]

Journal of Personalized Medicine, 2021
DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms can be activated by the cell for DNA repair: the accurate mechanism of homologous recombination repair or the error-prone non-homologous end joining. Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its ...
Wagener-Ryczek, Svenja, Merkelbach-Bruse, Sabine, Siemanowski, Janna   +2 more
openaire   +3 more sources

Multi-scale characterisation of homologous recombination deficiency in breast cancer [PDF]

Genome Medicine, 2023
Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier   +3 more
doaj   +3 more sources

Homologous Recombination Repair Deficiency: An Overview for Pathologists

Modern Pathology, 2023
The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prostate cancers.
Kenneth D. Doig, Andrew P. Fellowes, Stephen B. Fox   +2 more
openaire   +4 more sources

Supplementary Data from Detection of Molecular Signatures of Homologous Recombination Deficiency in Prostate Cancer with or without BRCA1/2 Mutations

, 2020
Supplementary Data from Detection of Molecular Signatures of Homologous Recombination Deficiency in Prostate Cancer with or without BRCA1/2 ...
Orsolya Rusz (6914750), Matthew L. Freedman (12504005), Miklos Diossy (15032135), Viktoria Tisza (10672539), István Csabai (130985), Mark M. Pomerantz (12504008), Zoltan Szallasi (58337), Zsofia Sztupinszki (15032132), Sandor Spisak (10672541), Marcin Krzystanek (402795), Judit Borcsok (15032138)   +10 more
core   +15 more sources

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency [PDF]

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +2 more sources

Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency

Genomics, Proteomics & Bioinformatics, 2023
Defects in genes involved in the DNA damage response cause homologous recombination repair deficiency (HRD). HRD is found in a subgroup of cancer patients for several tumor types, and it has a clinical relevance to cancer prevention and therapies ...
Wenbin Li, Lin Gao, Xin Yi, Shuangfeng Shi, Jie Huang, Leming Shi, Xiaoyan Zhou, Lingying Wu, Jianming Ying   +8 more
doaj   +3 more sources

Analysis of homologous recombination deficiency in prostate cancer

Сибирский онкологический журнал
Background. Mutations in homologous recombination repair (HRR) genes (BRCA2, ATM, CHEK2, NBN, etc.) are found in 20–25 % of patients with metastatic prostate cancer (PC) and are an indication for prescription of PARP inhibitors.
A. G. Iyevleva, S. N. Aleksakhina, A. P. Sokolenko, E. A. Otradnova, A. S. Nikitina, K. A. Kashko, M. V. Syomina, N. S. Morozova, A. D. Shestakova, E. Sh. Kuligina, E. N. Imyanitov   +10 more
doaj   +2 more sources

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data [PDF]

Life Science Alliance
Using somatic multi-omics data and explainable artificial intelligence, this study identifies novel alterations underlying homologous recombination repair deficiency across cancers.
Renan Valieris, Lucas Rosa, Luan Martins, Alexandre Defelicibus, Dirce Maria Carraro, Diana Noronha Nunes, Emmanuel Dias-Neto, Rafael Rosales, Israel Tojal da Silva   +8 more
doaj   +2 more sources

Supplementary Data from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response

, 2022
Supplementary Data from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic ...
Hyeon Gu Kang (14956288), Jung Kyoon Choi (9042119), Sinae Kim (245385), Eun Ji Lee (7377419), Eun-Hae Cho (14956297), Haeun Hwangbo (9042110), Byoung-Gie Kim (14956294), Jae-Weon Kim (836885), Suhwan Chang (3939071), Min Ji Park (5540663), Jung-Yun Lee (14956300), Myung Ji Kim (14956291)   +11 more
core   +6 more sources