Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
Clinics, 2018 Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio +3 more
exaly +3 more sources
Assessing the association between homologous recombination deficiency scores and treatment response in localized and metastatic prostate cancer [PDF]
The Journal of Pathology: Clinical ResearchThe aim of this study was to evaluate the predictive value of homologous recombination deficiency scores for therapeutic efficacy in prostate cancer across various disease stages under different regimens.
Qiyu Zhu +11 more
doaj +2 more sources
Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer [PDF]
Communications MedicineBackground Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1/BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC).
Helen R. Davies +18 more
doaj +2 more sources
Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency
Genomics, Proteomics and Bioinformatics, 2023 Defects in genes involved in the DNA damage response cause homologous recombination repair deficiency (HRD). HRD is found in a subgroup of cancer patients for several tumor types, and it has a clinical relevance to cancer prevention and therapies ...
Xiaoyan Zhou, leming Shi
exaly +3 more sources
Constitutional BRCA1 Methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer [PDF]
npj Breast CancerTumoral BRCA1 promoter methylation occurs frequently in triple-negative breast cancer (TNBC) and contributes to homologous recombination deficiency (HRD).
Justine Pasanisi +21 more
doaj +2 more sources
Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data [PDF]
Life Science AllianceUsing somatic multi-omics data and explainable artificial intelligence, this study identifies novel alterations underlying homologous recombination repair deficiency across cancers.
Renan Valieris +8 more
doaj +2 more sources
The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer [PDF]
Zhongguo aizheng zazhi, 2021 Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis ...
郁 俐 +4 more
doaj +2 more sources
Multi-scale characterisation of homologous recombination deficiency in breast cancer
Genome Medicine, 2023 Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson +3 more
doaj +1 more source
Homologous recombination proficiency in ovarian and breast cancer patients
BMC Cancer, 2021 Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden +7 more
doaj +1 more source
Leveraging homologous recombination repair deficiency in sarcoma
EMBO Molecular Medicine, 2023 Personalised oncology is at the forefront of cancer research. The goal of personalised oncology is to selectively kill cancer cells while minimising side effects on normal tissue.
Dea Slade, Joanna I Loizou
doaj +1 more source