Results 31 to 40 of about 52,625 (269)
Homologous Recombination Deficiency (HRD) in Cutaneous Oncology
International Journal of Molecular Sciences, 2023 Skin cancers, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (SCC), and melanoma, are the most common malignancies in the United States. Loss of DNA repair pathways in the skin plays a significant role in tumorigenesis. In recent years, targeting DNA repair pathways, particularly homologous recombination deficiency (HRD), has ...
Favour A. Akinjiyan +8 more
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Homologous recombination deficiency in breast cancer [PDF]
memo - Magazine of European Medical Oncology, 2020 SummaryBRCAmutation-related DNA repair deficiencies increase the individual sensitivity to DNA-targeting agents. Therefore, the patient’sBRCAmutational status is evaluated in clinical practice as a predictive marker in response to platinum salts and poly-ADP-ribose polymerase (PARP) inhibitors for breast cancer treatment.
Thomas Bartl, Alex Farr
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Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications [PDF]
The Oncologist, 2021 Abstract Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR genes are established cancer susceptibility genes with clinically actionable pathogenic variants (PVs).
MingRen, Toh, Joanne, Ngeow
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Blood Science, 2021 . Fanconi anemia (FA), an X-linked genetic or autosomal recessive disease, exhibits complicated pathogenesis. Previously, we detected the mutated Dynein Axonemal Heavy Chain 2 (DNAH2) gene in 2 FA cases.
Lixian Chang +13 more
doaj +1 more source
Utility of Homologous Recombination Deficiency Biomarkers Across Cancer Types [PDF]
JCO Precision Oncology, 2021 PURPOSE Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, pancreatic, and prostate. In these cancers, BRCA1/ 2 alterations and genomic scar signatures are useful indicators for assessing HRD. However, alterations
Shiro Takamatsu +9 more
openaire +3 more sources
iScience, 2021 Summary: The discovery of homologous recombination deficiency (HRD) biomarkers in prostate cancer is important for patients who will benefit from poly ADP-ribose polymerase inhibitor (PARPi).
Yawei Li +11 more
doaj +1 more source
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]
, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255) +61 more
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DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli. [PDF]
PLoS ONE, 2012 Even a partial loss of function of human RecQ helicase analogs causes adverse effects such as a cancer-prone Werner, Bloom or Rothmund-Thompson syndrome, whereas a complete RecQ deficiency in Escherichia coli is not deleterious for a cell.
Siniša Ivanković, Damir Đermić
doaj +1 more source
Homologous recombination deficiency: how genomic signatures are generated
Current Opinion in Genetics & Development, 2021 Cancer genomes harbor mutational and structural rearrangements that are jointly shaped by DNA damage and repair mechanisms. Accumulating evidence suggests that genetic alterations in DNA repair-defective tumors reflect the scars caused by the use of backup DNA repair mechanisms needed to maintain cellular viability. Detailed analysis of the patterns of
Jeremy, Setton +2 more
openaire +3 more sources
, 2022 Supplementary Figure from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic ...
Hyeon Gu Kang (14956288) +11 more
core +1 more source