Results 31 to 40 of about 762,366 (142)

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks [PDF]

, 2008
RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
Bradley Alison Sylvia, Tsaneva, I, Tsaneva Irina, Bénédicte Michel, Baharoglu Zeynep, Irina Tsaneva, Zeynep Baharoglu, Marie Le Masson, Michel, B, Bradley, AS, Baharoglu, Z, Le Masson Marie, Michel Bénédicte, Alison Sylvia Bradley, Le Masson, M   +14 more
core   +2 more sources

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

Nature Communications, 2022
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous ...
Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young   +18 more
doaj   +1 more source

Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length 'imprecise' intermediates [PDF]

, 2014
Recombination in enteroviruses provides an evolutionary mechanism for acquiring extensive regions of novel sequence, is suggested to have a role in genotype diversity and is known to have been key to the emergence of novel neuropathogenic variants of ...
David J Evans, Woodman, Andrew, Andrew Woodman, Kym Lowry (222718), Jonathan Cook (3435386), Andrew Woodman (577477), Cook, Jonathan, Cook, Jonathan P., David J. Evans (208308), Lowry, Kym, David J. Evans, Evans, David J., Kym Lowry, Jonathan Cook   +13 more
core   +1 more source

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks inmammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 [PDF]

, 2005
SJG-136, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine bases in a 5'-GATC-3' sequence in the DNA minor groove.
Hartley, J.A., Ghadessy, Farid J, De Silva, I.U., Thurston, DE, Thurston, D.E., Clingen, PH, Ghadessy, FJ, Tilby, M.J., De Silva, IU, De Silva, Inusha U, Tilby, Michael J, Hartley, JA, McHugh, Peter J, Ghadessy, F.J., Clingen, Peter H, McHugh, P.J., Tilby, MJ, Hartley, John A, Thurston, David E, Clingen, P.H., McHugh, PJ   +20 more
core   +1 more source

Supplementary Figure from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response

, 2022
Supplementary Figure from Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic ...
Hyeon Gu Kang (14956288), Jung Kyoon Choi (9042119), Sinae Kim (245385), Eun Ji Lee (7377419), Eun-Hae Cho (14956297), Haeun Hwangbo (9042110), Byoung-Gie Kim (14956294), Jae-Weon Kim (836885), Suhwan Chang (3939071), Min Ji Park (5540663), Jung-Yun Lee (14956300), Myung Ji Kim (14956291)   +11 more
core   +1 more source

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +1 more source

SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

Scientific Reports, 2017
SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis.
Yun-Ju Chen, Cheng-Hui Tsai, Pin-Yu Wang, Shu-Chun Teng   +3 more
doaj   +1 more source

Biomarkers for Homologous Recombination Deficiency in Cancer

, 2021
DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms can be activated by the cell for DNA repair: the accurate mechanism of homologous recombination repair or the error-prone non-homologous end joining.
Svenja Wagener-Ryczek, Janna Siemanowski, Sabine Merkelbach-Bruse   +2 more
core   +1 more source

Homologous Recombination Deficiency, Genetics, PARP Inhibitors, and Screening in Cancer

, 2023
Homologous Recombination Deficiency, Genetics, PARP Inhibitors, and Screening in Cancer, Amy Bodrog, MD, Lipson Cancer Institute Objectives: Discuss how PARP inhibitors work.
Bodrog, Amy
core  

Feasibility and cost-effectiveness of genetic counselling for all patients with newly diagnosed ovarian cancer: a single-centre retrospective study

Swiss Medical Weekly
BACKGROUND AND AIMS OF THE STUDY: Due to its importance for treatment and potential prevention in family members, germline testing for BRCA1/2 in patients with newly diagnosed ovarian cancer is decisive and considered a standard of care.
Saskia Schlootz, Flurina A. M. Saner , Manuela Rabaglio, Sara Imboden, Julian Wampfler   +4 more
doaj   +1 more source