Results 51 to 60 of about 762,366 (142)

SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers

The Journal of Clinical Investigation, 2022
Poly(ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells with homologous recombination DNA repair deficiency caused by mutations ...
Zhen Lu, Weiqun Mao, Hailing Yang, Janice M. Santiago-O’Farrill, Philip J. Rask, Jayanta Mondal, Hu Chen, Cristina Ivan, Xiuping Liu, Chang-Gong Liu, Yuanxin Xi, Kenta Masuda, Eli M. Carrami, Meng Chen, Yitao Tang, Lan Pang, David S. Lakomy, George A. Calin, Han Liang, Ahmed A. Ahmed, Hariprasad Vankayalapati, Robert C. Bast Jr.   +21 more
doaj   +1 more source

High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi [PDF]

, 2010
The study was funded by the Wellcome Trust. PS was supported by grants from the Wellcome Trust (073135) and British Infection Society.Orientia tsutsugamushi is an intracellular alpha-proteobacterium which resides in trombiculid mites, and is the ...
Feil, EJ, Sonthayanon Piengchan, Wuthiekanun Vanaporn, Stuart D Blacksell, Sharon J Peacock, Blacksell, SD, Bentley Stephen D., Sharon J. Peacock, Bentley, SD, Day, Nicholas P. J., Feil Edward J., Day Nicholas P. J., Stephen D. Bentley, Sonthayanon, P, Chierakul, Wirongrong, Stephen D Bentley, Blacksell, Stuart D., Chierakul Wirongrong, Piengchan Sonthayanon, Stuart D. Blacksell, Day, NP, Bentley, Stephen D., Nicholas P J Day, Holden, MT, Wirongrong Chierakul, Mathew T G Holden, Peacock, Sharon J., Feil, Edward J., Wuthiekanun, Vanaporn, Peacock, SJ, Edward J Feil, Wuthiekanun, V, Nicholas P. J. Day, Sonthayanon, Piengchan, Blacksell, Stuart, Vanaporn Wuthiekanun, Edward J. Feil, Chierakul, W, Peacock Sharon J., Day, Nicholas, Holden, Mathew T. G., Holden, Matthew, Blacksell Stuart D., Holden Mathew T. G., Mathew T. G. Holden   +44 more
core   +2 more sources

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]

, 2011
NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela, Bernd Baumann, Lisa Wiesmüller, Volcic, Meta, Fulda, Simone, Meta Volcic, Volcic, M., Wiesmueller, L., Baumann, B., Daniel, P., Sabine Karl, Simone Fulda, Daniela Salles, Peter Daniel, Karl, Sabine, Baumann, Bernd, Fulda, S., Salles, D., Karl, S., Daniel, Peter, Wiesmüller, Lisa   +20 more
core   +1 more source

Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review

Asian Journal of Oncology, 2019
Poly (ADP-ribose) polymerase (PARP) inhibitors are a unique class of therapeutic agents that focus on tumors with deficiencies in the homologous recombination DNA repair mechanism.
Vikas Goswami, Venkata Pradeep Babu Koyyala, Sumit Goyal, Manish Sharma, Varun Goel, Nilesh Dhamne, Udip Maheshwari, Atul Sharma   +7 more
doaj   +1 more source

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohort

BMC Cancer
Background Homologous recombination deficiency (HRD) is associated with sensitivity to platinum-based chemotherapy and PARP inhibitors in BRCA-associated cancers, including ovarian, breast, prostate, and pancreatic cancers.
Lili Ren, Runsi Yao, Ting Hou, Chenglin Liu, Fei Zhao, Xiaojun Chen, Zhou Zhang, Yan Huang   +7 more
doaj   +1 more source

Multiomics analysis of homologous recombination deficiency across cancer types

Biomolecules & Biomedicine
There remains ongoing debate regarding the association of homologous recombination deficiency (HRD) with patient survival across various malignancies, highlighting the need for a comprehensive understanding of HRD's role in different cancer types. Based
Lin Dong, Lin Li, Linyan Zhu, Fei Xu, Rumeng Zhang, Qiushuang Li, Yong Zhu, Zhutian Zeng, Keshuo Ding   +8 more
doaj   +1 more source

Homologous recombination deficiency in pancreatic neuroendocrine tumors. [PDF]

Future Oncol
Aim: Pancreatic Neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms whose tumor biology is still little known. Thanks to next-generation sequencing, pathogenic mutations in base-excision-repair MUTYH gene and homologous recombination ...
Bardasi C, Tenedini E, Bonamici L, Benatti S, Bonetti LR, Luppi G, Cortesi L, Tagliafico E, Dominici M, Gelsomino F.   +9 more
europepmc   +2 more sources

The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer

Cancer Biology & Medicine, 2020
Objective: Currently, there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC).
Yue Fan, Haifeng Ying, Xueying Wu, Huan Chen, Ying Hu, Henghui Zhang, Lijia Wu, Ying Yang, Beibei Mao, Lan Zheng   +9 more
doaj   +1 more source

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core  

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source