Results 61 to 70 of about 762,366 (142)

Determination of the DNA repair pathways utilised by acute lymphoblastic leukaemia cells following daunorubicin treatment

BMC Research Notes, 2019
Objective DNA double strand breaks (DNA-DSBs) are among the most lethal DNA lesions leading to genomic instability and repaired by either homologous recombination (HR) or the non-homologous end joining (NHEJ) mechanisms.
Hussain Mubarak Al-Aamri, Helen R. Irving, Terri Meehan-Andrews, Christopher Bradley   +3 more
doaj   +1 more source

Determinants of selectivity in Xer site-specific recombination [PDF]

, 1996
A remarkable property of some DNA-binding proteins that can interact with and pair distant DNA segments is that they mediate their biological function only when their binding sites are arranged in a specific configuration. Xer site-specific recombination
Blakely, G, Sherratt, D
core   +1 more source

Prediction of homologous recombination deficiency from Oncomine Comprehensive Assay Plus correlating with SOPHiA DDM HRD Solution.

PLoS ONE
ObjectivePoly(ADP-ribose) polymerase (PARP) inhibitors are used for targeted therapy for ovarian cancer with homologous recombination deficiency (HRD). In this study, we aimed to develop a homologous recombination deficiency prediction model to predict ...
Jun Kang, Kiyong Na, Haeyoun Kang, Uiju Cho, Sun Young Kwon, Sohyun Hwang, Ahwon Lee   +6 more
doaj   +1 more source

Somatic Kitl promotes mTOR to facilitate prophase I of meiosis in female embryonic gonads

Cell Death and Disease
Homologous synapsis and recombination are the central events that take place in the prophase I of meiosis. Signaling that promotes the germ cell differentiation and prophase I remains elusive.
Chang Liu, Ziyi Jin, Jiyu Chen, Jie Li, Guofeng Feng, Guoxing Yin, Yongqin Yu, Xiaoying Ye, Haowei Sun, Hua Zhang, Fei Gao, Lin Liu   +11 more
doaj   +1 more source

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

Nature Communications, 2019
High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and ...
Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P. Heinzen, Daniel R. O’Brien, Ann L. Oberg, S. John Weroha, Scott H. Kaufmann, Larry M. Karnitz   +9 more
doaj   +1 more source

Targeting homologous recombination repair defects in cancer

, 2010
DNA repair is essential for cells to maintain genome stability in an environment that constantly produces DNA damage. There is a growing appreciation that defects in homologous recombination repair underlie hereditary and sporadic tumourigenesis, and ...
Helleday, Thomas,, Jonkers, Jos, Thomas Helleday, Bastiaan Evers, Jos Jonkers, Evers, Bastiaan   +5 more
core   +1 more source

Genetics of DNA replication and homologous recombination in arabidopsis [PDF]

, 2005
The integrity of genetic information of each cell is constantly subjected to various threats, originating from environmental and endogenous sources.
Schürmann, David
core   +1 more source

Gene expression signature for predicting homologous recombination deficiency in triple-negative breast cancer

npj Breast Cancer
Triple-negative breast cancers (TNBCs) are a subset of breast cancers that have remained difficult to treat. A proportion of TNBCs arising in non-carriers of BRCA pathogenic variants have genomic features that are similar to BRCA carriers and may also ...
Jia-Wern Pan, Zi-Ching Tan, Pei-Sze Ng, Muhammad Mamduh Ahmad Zabidi, Putri Nur Fatin, Jie-Ying Teo, Siti Norhidayu Hasan, Tania Islam, Li-Ying Teoh, Suniza Jamaris, Mee-Hoong See, Cheng-Har Yip, Pathmanathan Rajadurai, Lai-Meng Looi, Nur Aishah Mohd Taib, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin, Joanna Lim, Soo-Hwang Teo   +19 more
doaj   +1 more source

Artemis over-expression and radiosensitivity in human cell lines [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The cellular radiosensitivity of two fibroblast cell lines derived from a breast cancer patient that “over-reacted” to radiotherapy (84BR) and a patient ...
Ulus-Senguloglu, Gonul
core   +3 more sources

How to measure homologous recombination deficiency in ovarian cancer

, 2017
Defective DNA repair via homologous recombination (HR) is common in ovarian high grade serous carcinomas, and homologous recombination deficiency (HRD) represents an important therapeutic target in epithelial ovarian cancers (EOCs).
Claudia Marchetti, Iain A. McNeish
core   +1 more source