Results 71 to 80 of about 762,366 (142)

Establishing the homologous recombination score threshold in metastatic prostate cancer patients to predict the efficacy of PARP inhibitors

Journal of the National Cancer Center
Background: The homologous recombination deficiency (HRD) score serves as a promising biomarker to identify patients who are eligible for treatment with PARP inhibitors (PARPi). Previous studies have suggested a 3-biomarker Genomic Instability Score (GIS)
Diwei Zhao, Anqi Wang, Yuanwei Li, Xinyang Cai, Junliang Zhao, Tianyou Zhang, Yi Zhao, Yu Dong, Fangjian Zhou, Yonghong Li, Jun Wang   +10 more
doaj   +1 more source

Protocol for detecting homologous recombination activity in cancer cells by adenovirus-based functional assay

STAR Protocols
Summary: Cancer cells with homologous recombination deficiency (HRD) exhibit a distinctive vulnerability to poly(ADP-ribose) polymerase inhibitors (PARPis).
Shih-Han Huang, Chih-Ying Lee, Peter Chi
doaj   +1 more source

Proteasome inhibition induces a BRCAness-like state and sensitises HR-proficient ovarian cancer models to PARP inhibitors

Frontiers in Immunology
BackgroundPoly (ADP-ribose) polymerase inhibitors (PARPi) have improved outcomes in ovarian cancer with homologous recombination deficiency (HRD). However, approximately half of high-grade serous ovarian cancers retain intact homologous recombination ...
Ruiju He, Ruiju He, Yingting Wei, Yingting Wei, Jing Niu, Jing Niu, Jinghua Huang, Jinghua Huang, Ruolan Wu, Ruolan Wu, Kaiyan Gu, Kaiyan Gu, Anyue Wu, Anyue Wu, Lihua Qiu, Lihua Qiu, Lihua Qiu   +16 more
doaj   +1 more source

A deep-learning-based genomic status estimating framework for homologous recombination deficiency detection from low-pass whole genome sequencing

Heliyon
Genome-wide sequencing allows for prediction of clinical treatment responses and outcomes by estimating genomic status. Here, we developed Genomic Status scan (GSscan), a long short-term memory (LSTM)-based deep-learning framework, which utilizes low ...
Yang Liu, Xiang Bi, Yang Leng, Dan Chen, Juan Wang, Youjia Ma, Min-Zhe Zhang, Bo-Wei Han, Yalun Li   +8 more
doaj   +1 more source

The use of PARP inhibitors as maintenance therapy in ovarian carcinosarcoma: A case series

Gynecologic Oncology Reports
Objective: Carcinosarcoma an aggressive subtype of ovarian cancer. While treatment consists primarily of cytoreductive surgery followed by platinum-based chemotherapy, maintenance therapy can also be considered. Limited data exists on the use of poly ADP-
Andreea I Dinicu, Peter G Rose
doaj   +1 more source

Over Two Years of Sustained Remission With Olaparib Monotherapy in Stage IV Non‐Small Cell Lung Cancer With ATM Mutation: A Case Report

Cancer Reports
Background Ataxia telangiectasia mutated (ATM) mutations represent the most common homologous recombination deficiency (HRD) mutation in non‐small cell lung cancer (NSCLC). However, their therapeutic role in NSCLC has not been established.
Zhiting Tang, Ran Bi, Mutasim Idriss, Qian Wang, Qi Wang, Makiko Ban‐Hoefen   +5 more
doaj   +1 more source

Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking [PDF]

, 2009
The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for seasonal influenza, as well as development of similar ...
Henry L. Niman
core  

Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

Drug Design, Development and Therapy, 2018
Domenica Lorusso, Elisa Tripodi, Giuseppa Maltese, Stefano Lepori, Ilaria Sabatucci, Giorgio Bogani, Francesco Raspagliesi Gynecologic Oncology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy Abstract: Epithelial ovarian cancer is ...
Lorusso D, Tripodi E, Maltese G, Lepori S, Sabatucci I, Bogani G, Raspagliesi F   +6 more
doaj  

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer. [PDF]

MedComm (2020)
Zhang X, Xu H, Wang K, Hu W.
europepmc   +1 more source

Deep learning-based prediction of homologous recombination deficiency from histopathological whole-slide images in ovarian cancer

International audienceHomologous recombination deficiency is a critical biomarker for guiding first-line treatment with poly(adenosine diphosphate-ribose) polymerase inhibitors in ovarian cancer. While genomic assays are the current standard, they remain
Salhi, Sanae, Salhi, Yahia, Heudel, Pierre-Etienne, Frenel, Jean-Sébastien, Rynkiewicz, Joseph, Ray-Coquard, Isabelle, Guinaudeau, Emmanuelle, Bossard, Céline, Chetritt, Jérôme, Pujade-Lauraine, Eric, Lindahl, Gabriel   +10 more
core   +1 more source