Results 201 to 210 of about 137,826 (378)

Establish of an Initial Platinum-Resistance Predictor in High-Grade Serous Ovarian Cancer Patients Regardless of Homologous Recombination Deficiency Status [PDF]

, 2022
Yongmei Li, Yufei Nie, Hongyan Guo, Hua Guo, Chunfang Ha, Yuan Li, Yuan Li, Yuan Li   +7 more
openalex   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Supplementary Methods, Figure Legends, Table Legends from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers [PDF]

, 2023
Johnathan Watkins, Daniel Weekes, Vandna Shah, Patrycja Gazińska, Shalaka Joshi, Bhavna Sidhu, Cheryl Gillett, Sarah E. Pinder, Fabio Vanoli, Maria Jasin, Markus Mayrhofer, Anders Isaksson, Maggie C.U. Cheang, Hasan Mirza, Jessica Frankum, Christopher J. Lord, Alan Ashworth, Shaveta Vinayak, James M. Ford, Melinda L. Telli, Anita Grigoriadis, Andrew Tutt   +21 more
openalex   +1 more source

Molecular genetics of development studied in the transgenic mouse. [PDF]

, 1989
Gruss, P., Westphal, H.
core   +2 more sources

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Twelve mutations, three trials, and five different labels: PARP inhibitors regulatory inconsistencies in prostate cancers

EClinicalMedicine
Summary: Three different PARP (Poly (ADP-ribose) Polymerase)-inhibitors have been approved in combination with androgen receptor pathway inhibitors (ARPIs) for the treatment of metastatic castration-resistant prostate cancer (mCRPC).
Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Hans M. Westgeest, Timothée Olivier   +2 more
doaj   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation [PDF]

, 2023
Nikhil Sahajpal, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Andy Wing Chun Pang, Daniel Saul, Omar Nivin, Benjamin Hilton, Barbara R. DuPont, Vamsi Kota, Natasha M. Savage, Alex Hastie, Alka Chaubey, Ravindra Kolhe   +13 more
openalex   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, EarlyView.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides

Angewandte Chemie, EarlyView.
We present a high‐throughput selection system to engineer fluoroacetate dehalogenases (FAcDs). By challenging E. coli populations that produce diverse FAcD libraries to grow on non‐natural organofluorides as their sole carbon source, we isolated a panel of FAcD variants with improved activity and altered substrate specificity.
Suzanne C. Jansen, Pauline van Beers, Clemens Mayer   +2 more
wiley   +2 more sources