Results 221 to 230 of about 91,698 (296)

Homologous recombination deficiency in newly diagnosed advanced ovarian cancer across nine Middle East countries: prevalence, real-world testing pathways, and treatment implications. [PDF]

BMC Cancer
Shash E, Vardar MA, Taskiran C, Boujassoum S, Riromar J, Aboutaleb A, Sadek F, Samy E, Bahaj W.   +8 more
europepmc   +1 more source

Information Dynamics and Learning in Complex Adaptive Systems: Toward a Transdisciplinary Framework

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This article develops a framework for understanding learning and adaptation in complex adaptive systems. Drawing from neuroscience, systems theory, information theory and quantum field theory, it examines how information processing, plasticity and systemic coherence emerge from distributed, nonlinear and feedback‐driven interactions. It argues
Anderson de Souza Sant'Anna
wiley   +1 more source

CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer. [PDF]

Commun Biol
Romanovsky E, Menzel M, Kluck K, Beck S, Ball M, Schirmacher P, Kazdal D, Stenzinger A, Budczies J.   +8 more
europepmc   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Homologous recombination deficiency in breast cancer: genomic characteristics, clinical implications, and predictive value in neoadjuvant therapy. [PDF]

Front Oncol
Huang J, Luan F, Yan L, Liang X, Ma X, An Y, Hu S, Gao G, Wang Y, Yang J, Dong D.   +10 more
europepmc   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas. [PDF]

Int J Mol Sci
Iyevleva AG, Aleksakhina SN, Sokolenko AP, Otradnova EA, Nikitina AS, Kashko KA, Syomina MV, Shestakova AD, Kuligina ES, Morozova NS, Popov SV, Vyazovcev PV, Luchkova TY, Peremyshlenko AS, Topuzov TM, Gudkova OM, Orlova RV, Levushkin AV, Moiseev DO, Shkodenko ON, Gubarev DV, Dzyuba AV, Povorina IY, Agaeva AV, Kutyan VF, Grigoryan MM, Orlov AN, Lefterov SI, Belousov AV, Nechaeva MN, Vorobyeva EN, Amirkhanova IK, Kryukova NV, Zatulivetrova LI, Gomboeva AB, Krivtsov VN, Shchiglik OI, Prokudina NV, Butunina NA, Belyaev AM, Imyanitov EN.   +40 more
europepmc   +1 more source

XLF and H2AX function in series to promote replication fork stability [PDF]

, 2019
Berti, Matteo, Bredemeyer, Andrea L, Byrum, Andrea K, Chen, Bo-Ruei, Hindi, Issa, Jackson, Jessica, Mosammaparast, Nima, Quinet, Annabel, Sleckman, Barry P, Thangavel, Saravanabhavan, Tyler, Jessica K, Vindigni, Alessandro   +11 more
core   +1 more source

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

Yeast, EarlyView.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias, Fernanda Pinheiro Moreira Freitas, Eduardo Luís Menezes de Almeida, Luciano Gomes Fietto, Agustin Zsögön, Wendel Batista da Silveira   +5 more
wiley   +1 more source

A Novel Droplet Digital PCR Assay for BRCA1 and RAD51C Methylation: Advancing Homologous Recombination Deficiency Detection in Ovarian Cancer. [PDF]

J Mol Diagn
Michel C, Simon A, Witz A, Hanriot I, Dardare J, Betz M, Brun M, Gilson P, Merlin JL, Harlé A.   +9 more
europepmc   +1 more source