Results 71 to 80 of about 137,826 (378)

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

Nature Communications, 2022
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous ...
Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young   +18 more
doaj   +1 more source

Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study

International Journal of Gynecological Cancer, 2023
Objective Olaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination.
R. Morgan, A. Clamp, Bethany M. Barnes, K. Timms, H. Schlecht, L. Yarram-Smith, Y. Wallis, Mikel Valganon-Petrizan, S. Macmahon, Rhian White, S. Morgan, S. McKenna, E. Hudson, L. Tookman, A. George, R. Manchanda, S. Sundar, S. Nicum, J. Brenton, R. Kristeleit, Susana Banerjee, I. McNeish, J. Ledermann, Stephen S. Taylor, D. Evans, G. Jayson   +25 more
semanticscholar   +1 more source

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania [PDF]

, 2016
The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways in eukaryotic cells. This PCNA-related trimer is loaded onto RPA-coated single stranded DNA and interacts with
Damasceno, Jeziel D., McCulloch, Richard, Obonaga, Ricardo, Santos, Elaine V., Scott, Alan, Tosi, Luiz R.O.   +5 more
core   +1 more source

Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: The elevated levels of somatic copy-number alterations (SCNAs) in a subset of high-risk endometrial cancers are suggestive of defects in pathways governing genome integrity. We sought to assess the prevalence of homologous recombination deficiency (HRD) in endometrial cancers ...
Jonge, D, Auguste, A, Van Wijk, L, Schouten, P, Meijers, M, Ter Haar, N, Smit, V, Nout, R, Glaire, M, Church, D, Vrieling, H, Job, B, Boursin, Y, De Kroon, C, Rouleau, E, Leary, A, Vreeswijk, M, Bosse, T   +17 more
openaire   +3 more sources

Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology

Communications Biology, 2023
Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose polymerase (PARP) inhibitors as well as the ...
Huizi Yao, Huimin Li, Jinyu Wang, Tao Wu, Wei Ning, Kaixuan Diao, Chenxu Wu, Guangshuai Wang, Ziyu Tao, Xiangyu Zhao, Jing Chen, Xiaoqin Sun, Xue-song Liu   +12 more
semanticscholar   +1 more source

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]

, 2014
BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Abdel-Fatah, TMA, Agarwal, D, Albarakati, N, Alsubhi, N, Arora, A, Ball, G, Caldas, C, Chan, S, Doherty, R, Ellis, IO, Green, A, Madhusudan, S, Moseley, P, Perry, C, Rakha, EA, Russell, R, Seedhouse, C   +16 more
core   +1 more source

RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis

Oncology Letters, 2023
Tumors harboring homologous recombination deficiency (HRD) are considered optimal candidates for poly(ADP-ribose) polymerase 1 (PARP) inhibitor treatment.
Aikaterini Tsantikidi, Konstantinos Papazisis, T. Floros, M. Gazouli, E. Papadopoulou, Georgios N. Tsaousis, Georgios Nasioulas, Andra Mester, Kubelac Milan, Bogdan Gozman, V. Afrăsânie, D. Stănculeanu, O. Trifănescu, F. Pescaru, Claudia Militaru, Christos Papadimitriou   +15 more
semanticscholar   +1 more source

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity [PDF]

, 2019
The BARD1 protein, which heterodimerizes with BRCA1, is encoded by a known breast cancer susceptibility gene. While several BARD1 variants have been identified as pathogenic, many more missense variants exist that do not occur frequently enough to assign
Adamovich, Aleksandra I, Banerjee, Tapahsama, Chen, Feng, Ding, Li, Duncan, Kathryn, Huang, Kuan-lin, Lee, Cindy, Ning, Jie, Parvin, Jeffrey D, Rodrigues, Fernanda Martins, Wingo, Margaret   +10 more
core   +3 more sources

Homologous Recombination Deficiency in Pancreatic Cancer: A Systematic Review and Prevalence Meta-Analysis

Journal of Clinical Oncology, 2021
PURPOSE To analyze the prevalence of homologous recombination deficiency (HRD) in patients with pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS We conducted a systematic review and meta-analysis of the prevalence of HRD in PDAC from PubMed,
R. Casolino, S. Paiella, D. Azzolina, P. Beer, V. Corbo, G. Lorenzoni, D. Gregori, T. Golan, C. Braconi, F. Froeling, M. Milella, A. Scarpa, A. Pea, G. Malleo, R. Salvia, C. Bassi, D. Chang, A. Biankin   +17 more
semanticscholar   +1 more source

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 [PDF]

, 2009
Homologous recombination (HR) and non‐homologous end joining (NHEJ) represent distinct pathways for repairing DNA double‐strand breaks (DSBs). Previous work implicated Artemis and ATM in an NHEJ‐dependent process, which repairs a defined subset of ...
Aaron A Goodarzi, Andrea Beucher, Andrea Krempler, Atsushi Shibata, Darroudi F, Julie Birraux, Leopoldine Tchouandong, Markus Löbrich, Olivia Barton, Penny A Jeggo, Sandro Conrad, Sonoda E, Taghian DG, Yuan SS   +13 more
core   +3 more sources