Results 81 to 90 of about 137,826 (378)

SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

Scientific Reports, 2017
SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis.
Yun-Ju Chen, Cheng-Hui Tsai, Pin-Yu Wang, Shu-Chun Teng   +3 more
doaj   +1 more source

How BRCA and homologous recombination deficiency change therapeutic strategies in ovarian cancer: a review of literature

Frontiers in Oncology
About 50% of High Grade Serous Ovarian Cancer exhibit a high degree of genomic instability due to mutation of genes involved in Homologous Recombination (HRD) and such defect accounts for synthetic lethality mechanism of PARP inhibitors (PARP-i). Several
M. Arcieri, V. Tius, C. Andreetta, S. Restaino, A. Biasioli, Elena Poletto, Giuseppe Damante, A. Ercoli, L. Driul, A. Fagotti, Domenica Lorusso, G. Scambia, Giuseppe Vizzielli   +12 more
semanticscholar   +1 more source

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis [PDF]

, 2010
Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata.
Choi, Y, Erdin, SU, Kloc, M, Meistrich, ML, Rajkovic, A, Shin, YH, Wang, PJ, Yang, F, Yatsenko, SA   +8 more
core   +5 more sources

Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency

Genomics, Proteomics & Bioinformatics, 2023
Defects in genes involved in the DNA damage response cause homologous recombination repair deficiency (HRD). HRD is found in a subgroup of cancer patients for several tumor types, and it has a clinical relevance to cancer prevention and therapies ...
Wenbin Li, Lin Gao, Xin Yi, Shuangfeng Shi, Jie Huang, Leming Shi, Xiaoyan Zhou, Lingying Wu, Jianming Ying   +8 more
doaj   +1 more source

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

JCO Precision Oncology
PURPOSE Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown promising clinical results in the treatment of ovarian cancer. Analysis of biomarker subgroups consistently revealed higher benefits for patients with homologous recombination deficiency ...
N. Pfarr, Karin von Schwarzenberg, D. Zocholl, Sabine Merkelbach-Bruse, J. Siemanowski, Eva-Maria Mayr, Sylvia Herold, Karsten Kleo, Lukas C Heukamp, E. Willing, Michael Menzel, Ulrich Lehmann, S. Bartels, Shounak Chakraborty, G. Baretton, M. Demes, Claudia Döring, D. Kazdal, J. Budczies, Roland Rad, Peter Wild, Y. Christinat, Thomas Mckee, P. Schirmacher, David Horst, Reinhard Büttner, A. Stenzinger, J. Sehouli, C. Vollbrecht, Michael Hummel, E. Braicu, Wilko Weichert   +31 more
semanticscholar   +1 more source

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +1 more source

Prevalence of Homologous Recombination Deficiency Among Patients With Germline RAD51C/D Breast or Ovarian Cancer

JAMA Network Open
Key Points Question What is the prevalence of homologous recombination deficiency (HRD) in tumors from patients with germline RAD51C/D breast and ovarian cancer?
S. Torres-Esquius, A. Llop-Guevara, S. Gutiérrez‐Enríquez, Marcel Romey, À. Teulé, G. Llort, Ana Herrero, P. Sánchez-Henarejos, A. Vallmajó, S. González-Santiago, I. Chirivella, J. Cano, Begoña Graña, Sara Simonetti, Isabela Díaz de Corcuera, T. Ramón y Cajal, J. Sanz, Sara Serrano, Andrea Otero, C. Churruca, A. Sánchez-Heras, S. Servitja, C. Guillén-Ponce, Joan Brunet, Carsten Denkert, V. Serra, Judith Balmaña   +26 more
semanticscholar   +1 more source

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]

, 2014
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ, Bähler, J, Deegan, RS, Hulme, L, Humphrey, TC, Hussey, S, Kasparek, TR, Marguerat, S, Nakagawa, T, Pai, CC, Sarkar, S, Tinline-Purvis, H, Walker, CA, Wee, BY   +13 more
core   +1 more source

Homologous recombination deficiency in triple negative breast cancer

The Breast, 2019
Triple negative breast cancer (TNBC) represents a heterogeneous subtype of breast cancer characterized by an unfavorable prognosis due to its aggressive biology. The median overall survival (OS) for patients with metastatic TNBC is around 9-12 months with conventional cytotoxic agents.
Belli C., Duso B. A., Ferraro E., Curigliano G.   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source