Results 71 to 80 of about 473,693 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective. [PDF]

, 2011
Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of ...
Kerac, Marko, Zanuzdana, A, Augustine, G, Kim, Sophie, Mukaigawara, M, Denness, H, Harris, Rebecca C., Parish, V, Stevenson, Charlotte, Wigglesworth, N, Haroon, M, Paul Fisher, Javier Peñalver, Beck, Charles R., Gemma Morgan, Charlotte Stevenson, Butt, Mobasher, Puleston, Richard, Vivienne Parish, Haroon, S, Rebecca C Harris, Hiroshi Horiuchi, Ahyow, L, Bruce C McKenzie, Jose Figureroa, Joanne Enstone, Marko Kerac, Puleston, R, Dabke, G, Figureroa, Jose, Hashim, Ahmed B., Nguyen-Van-Tam, JS, Ishola, David A, Peñalver, Javier, Figureroa, J, Mobasher Butt, Mary O'Brien, Hird, C, Laura Béchard-Evans, Harris, Rebecca, Wigglesworth, Neil, Glenda Augustine, Richard Puleston, Ishola, DA, Isba, Rachel, Felix Greaves, Peñalver, J, Sophie Kim, McKenzie, Bruce C., Béchard-Evans, L, Agboado, Gabriel, Weston, Rachel, Orton, Elizabeth, Liz Lingard, Caroline Hird, Stevenson, C, Augustine, Glenda, O'Boyle, J, Hashim, Ahmed B, Dabke, Girija, Rachel Isba, Morgan, Gemma, Theaker, S, Ishola, David A., Kerac, M, O'Brien, Mary, Mitsuru Mukaigawara, Elizabeth Orton, Beck, Charles, Theaker, Sarah, Rosser, Julia, Vinogradova, Yana, Siobhan Farmer, Dean Wallace, Horiuchi, Hiroshi, Weston, R, Vinogradova, Y, Béchard-Evans, Laura, Sophie Haroon, Wallace, D, O'Boyle, Julie, Nguyen-Van-Tam, Jonathan S, Neil Wigglesworth, Haroon, Sophie, Hashim, Ahmed, Helene Denness, Wallace, Dean, Lingard, L, Zanuzdana, Arina, Munib Haroon, McKenzie, Bruce C, Nguyen-Van-Tam, Jonathan, Agboado, G, Horiuchi, H, David A Ishola, Harris, Rebecca C, Gabriel Agboado, Rachel Weston, Yana Vinogradova, Nguyen-Van-Tam, Jonathan S., Robert Howard, Beck, CR, Orton, E, Kim, S, Lauren Ahyow, Jonathan S Nguyen-Van-Tam, Roberts, Jonathan, Fisher, P, Farmer, S, Jonathan Roberts, Ishola, David, Lingard, Liz, Enstone, Joanne, Howard, Robert, Greaves, Felix, Howard, R, Denness, Helene, Isba, R, Fisher, Paul, Enstone, J, Hird, Caroline, Julie O'Boyle, Harris, RC, Haroon, Munib, Mukaigawara, Mitsuru, Rosser, J, Girija Dabke, Arina Zanuzdana, Sarah Theaker, Butt, M, Greaves, F, McKenzie, BC, Ahyow, Lauren, Hashim, AB, Morgan, G, Farmer, Siobhan, Ahmed B Hashim, Charles R Beck, Beck, Charles R, Parish, Vivienne, Julia Rosser, McKenzie, Bruce, O'Brien, M, Roberts, J, Zanuzdana Arina, Morgan Gemma, Lingard Liz, Kerac Marko, Denness Helene, Kim Sophie, Orton Elizabeth, Agboado Gabriel, McKenzie Bruce C., Enstone Joanne, Parish Vivienne, Dabke Girija, Greaves Felix, Vinogradova Yana, Béchard-Evans Laura, Mukaigawara Mitsuru, Augustine Glenda, Roberts Jonathan, Weston Rachel, Haroon Munib, Hashim Ahmed B., Howard Robert, Isba Rachel, O'Boyle, J, O'Brien Mary, Theaker Sarah, Peñalver Javier, Beck Charles R., Wallace Dean, Rosser Julia, O'Boyle Julie, Ahyow Lauren, Puleston Richard, Stevenson Charlotte, Haroon Sophie, Ishola David A., Harris Rebecca C., Horiuchi Hiroshi, Fisher Paul, O'Brien, M, Figureroa Jose, Hird Caroline, Butt Mobasher, Nguyen-Van-Tam Jonathan S., Wigglesworth Neil, Farmer Siobhan   +189 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Association of Homologous and Heterologous Vaccine Boosters With SARS-CoV-2 Infection in BBIBP-CorV Vaccinated Healthcare Personnel

Cureus, 2022
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played a crucial role in mitigating the coronavirus disease 2019 (COVID-19) pandemic. However, few studies have addressed the optimal booster vaccine type in recipients of the primary series of BBIBP-CorV (an inactivated virus vaccine developed by Sinopharm).
Park, Sungsoo, Gatchalian, Katrine K, Oh, Hyeyoung   +2 more
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Homologous or heterologous administration of mRNA or adenovirus-vectored vaccines show comparable immunogenicity and effectiveness against the SARS-CoV-2 Omicron variant

Expert Review of Vaccines
Background Heterologous prime-boost schedules have been employed in SARS-CoV-2 vaccination, yet additional data on immunogenicity and effectiveness are still needed.Research design and methods Here, we measured the immunogenicity and effectiveness in the
Gabiria Pastore, Jacopo Polvere, Fabio Fiorino, Simone Lucchesi, Giorgio Montesi, Ilaria Rancan, Sara Zirpoli, Arianna Lippi, Miriam Durante, Massimiliano Fabbiani, Mario Tumbarello, Francesca Montagnani, Donata Medaglini, Annalisa Ciabattini   +13 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Booster doses of an inactivated F genotype mumps vaccine enhance immunogenicity in mice

Vaccine: X
The mumps virus (MuV) causes a highly contagious human disease characterized by swelling of the parotid glands. Although the administration of an attenuated Jeryl Lynn (JL) MuV vaccine shows efficacy in reducing the incidence of MuV infection, sporadic ...
Seo Yeon Kim, Tae-Young Lee, Yun-Ho Hwang, Dokeun Kim, You-Jin Kim, Hyeran Won   +5 more
doaj   +1 more source