Results 71 to 80 of about 1,026,270 (282)

Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration

open access: yesEuropean Journal of Medical Research
Objectives This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells.
Gao Han   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Analyzing the impact of conflictive dental characters on the phylogeny of octodontoid rodents [PDF]

open access: yesActa Palaeontologica Polonica, 2016
Systematics of fossil octodontoids (Rodentia, Caviomorpha) is in great part based on insights into the knowledge of teeth, making the step of dental characterization certainly relevant for the evolutionary reconstruction of these rodents.
Adriana M. Candela
doaj   +1 more source

Homological descent for motivic homology theories [PDF]

open access: yesHomology, Homotopy and Applications, 2014
We show that motivic homology, motivic Borel-Moore homology and higher Chow groups satisfy homological descent for hyperenvelopes, and l-hyperenvelopes after inverting l.
openaire   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Morphological homology, evolution, and proposed nomenclature for bear dentition [PDF]

open access: yesActa Palaeontologica Polonica, 2019
Bears are a group of carnivores with diverse diets and complicated dental structure. Several large rearrangements of dental structures are known in different lineages of bears, making the homology of dental structures between the different bears ...
Qigao Jiangzuo, Jinyi Liu, Jin Chen
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Action minimizing solutions of the Newtonian n-body problem: from homology to symmetry

open access: yes, 2002
An action minimizing path between two given configurations, spatial or planar, of the $n$-body problem is always a true -- collision-free -- solution.
A. Chenciner, Homology To Symmetry
core   +2 more sources

Twisted K-homology,Geometric cycles and T-duality [PDF]

open access: yes, 2014
Twisted $K$-homology corresponds to $D$-branes in string theory. In this paper we compare two different models of geometric twisted $K$-homology and get their equivalence.
Liu, Bei
core  

Modular Homology Characters [PDF]

open access: yesProceedings of the National Academy of Sciences, 1932
This paper gives definitions and some simple properties of homology characters modulo any integer preceded by a discussion of matrices modulo any integer.
openaire   +3 more sources

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