Results 31 to 40 of about 405,413 (267)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Pirashvili–Richter-type theorems for the reflexive and dihedral homology theories

Comptes Rendus. Mathématique
Reflexive homology and dihedral homology are the homology theories associated to the reflexive and dihedral crossed simplicial groups respectively. The former has recently been shown to capture interesting information about $C_2$-equivariant homotopy ...
Graves, Daniel
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Proteomic Style Approach To Characterize a Grass Mix Product Reveals Potential Immunotherapeutic Benefit

World Allergy Organization Journal, 2011
Background Grass allergy immunotherapies often consist of a mix of different grass extracts, each containing several proteins of different physiochemical properties; however, the subtle contributions of each protein are difficult to elucidate. This study
Alan Bullimore, BSc, Nicola Swan, MSc, Wemimo Alawode, PhD, Murray Skinner, PhD   +3 more
doaj   +1 more source

The Homology of Warped Product Submanifolds of Spheres and Their Applications

Mathematics, 2023
The aim of the current article is to formulate sufficient conditions for the Laplacian and a gradient of the warping function of a compact warped product submanifold Σβ1+β2 in a unit sphere Sd that provides trivial homology and fundamental groups.
Lamia Saeed Alqahtani, Akram Ali, Pişcoran Laurian-Ioan, Ali H. Alkhaldi   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Unraveling chaos: A topological analysis of simplicial homology groups and their foldings

Open Mathematics
In this article, we introduce a new type of simplicial homology group called the chaotic simplicial homology group. We construct the structure of this group and obtain some types of conditional foldings and unfoldings restricted to the elements of the ...
Abu-Saleem Mohammed
doaj   +1 more source

Topological analysis of number theory and its applications in quantum cryptography [PDF]

مجلة جامعة الانبار للعلوم الصرفة
This study investigates the application of algebraic topology, in particular homology theory and persistent homology. It includes the analysis of elliptic curves and their use in cryptographic systems and cybersecurity.
Noor Kadhim, Ruaa Abd, Saja AL-Khafaji
doaj   +1 more source