Results 41 to 50 of about 405,413 (267)
Alteration in the Local and Global Functional Connectivity of Resting State Networks in Parkinson’s Disease [PDF]
Journal of Movement Disorders, 2018 Objective Parkinson’s disease (PD) is a neurodegenerative disorder that mainly leads to the impairment of patients’ motor function, as well as of cognition, as it progresses.
Maryam Ghahremani +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The homology groups of the Cartesian product $\Omega_{n_1}(m_1)\times \Omega_{n_2}(m_2)$
Researches in MathematicsThe paper continues the investigation of the spaces of complex-valued perfect splines $\Omega_n(m)$. These spaces were introduced as generalization of the spaces $\Omega_n$, the topology of which has been studied by V.I. Ruban, V.A. Koshcheev, A.M. Pasko.
A.M. Pasko
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
cDNA cloning and molecular modeling of procerain B, a novel cysteine endopeptidase isolated from Calotropis procera. [PDF]
PLoS ONE, 2013 Procerain B, a novel cysteine protease (endopeptidase) isolated from Calotropis procera belongs to Asclepiadaceae family. Purification of the enzyme, biochemical characterization and potential applications are already published by our group.
Abhay Narayan Singh +2 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
The homology of the Higman–Thompson groups [PDF]
Inventiones mathematicae, 2019 49 ...
Szymik, Markus, Wahl, Nathalie
openaire +5 more sources
The topology of restricted partition posets [PDF]
Discrete Mathematics & Theoretical Computer Science, 2011 For each composition $\vec{c}$ we show that the order complex of the poset of pointed set partitions $Π ^• _{\vec{c}}$ is a wedge of $β\vec{c}$ spheres of the same dimensions, where $β\vec{c}$ is the number of permutations with descent composition ^$\vec{
Richard Ehrenborg, JiYoon Jung
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source