Results 61 to 70 of about 405,413 (267)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A limit approach to group homology
Journal of Algebra, 2008 In this paper, we consider for any free presentation $G = F/R$ of a group $G$ the coinvariance $H_{0}(G,R_{ab}^{\otimes n})$ of the $n$-th tensor power of the relation module $R_{ab}$ and show that the homology group $H_{2n}(G,{\mathbb Z})$ may be identified with the limit of the groups $H_{0}(G,R_{ab}^{\otimes n})$, where the limit is taken over the ...
Emmanouil, I., Mikhailov, R.
openaire +3 more sources
Bioinformation analysis of rotavirus vaccine efficiency
Фармацевтичний журнал, 2019 A couple of studies have shown that viruses cause from 25 to 60% of acute intestinal infections (AII) cases, among which rotaviruses play a leading role in the structure of children's AII of viral etiology.
S. O. Soloviov +2 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
International Journal of COPD, 2016 Mizuho Nishio,1 Kazuaki Nakane,2 Yutaka Tanaka3 1Clinical PET Center, Institute of Biomedical Research and Innovation, Hyogo, Japan; 2Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan ...
Nishio M, Nakane K, Tanaka Y
doaj
A group of segmented viruses contains genome segments sharing homology with multiple viral taxa
Journal of VirologyThe discovery of diverse segmented RNA viruses through metatranscriptomics has enabled researchers to trace their evolutionary trajectories. However, this effort has been hindered by the limited availability of complete genome sequences and the low ...
Huang Huang +12 more
doaj +1 more source
Проблемы особо опасных инфекций, 2013 Fully sequenced have been glycoprotein-G, sha-psi region, as well as H-end site of the L-gene in the rabies virus strain “Moscow 3253”. Compared are amino acid sequences of proteins of “Moscow 3253” strain and other fixed strains of the virus ...
I. V. Tuchkov +6 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Algebraic Structures Based on a Classifying Space of a Compact Lie Group
Abstract and Applied Analysis, 2013 We analyze the algebraic structures based on a classifying space of a compact Lie group. We construct the connected graded free Lie algebra structure by considering the rationally nontrivial indecomposable and decomposable generators of homotopy groups ...
Dae-Woong Lee
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source