Results 41 to 50 of about 539,595 (279)
Current Directions in Biomedical Engineering, 2021 Primary sclerosis cholangitis (PSC) predisposes individuals to liver failure, but it is challenging for radiologists examining radiologic images to predict which patients with PSC will ultimately develop liver failure.
Singh Yashbir +8 more
doaj +1 more source
A Spatiotemporal Brain Network Analysis of Alzheimer’s Disease Based on Persistent Homology
Frontiers in Aging Neuroscience, 2022 Current brain network studies based on persistent homology mainly focus on the spatial evolution over multiple spatial scales, and there is little research on the evolution of a spatiotemporal brain network of Alzheimer’s disease (AD).
Jiacheng Xing +4 more
doaj +1 more source
Homology stability for outer automorphism groups of free groups
, 2004 We prove that the quotient map from Aut(F_n) to Out(F_n) induces an isomorphism on homology in dimension i for n at least 2i+4. This corrects an earlier proof by the first author and significantly improves the stability range. In the course of the proof,
Allen Hatcher +4 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes. [PDF]
PLoS ONE, 2010 Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders. Large mtDNA deletions can lead to a broad spectrum of clinical features with different age of onset, ranging from mild mitochondrial myopathies (MM), progressive external ...
Bekim Sadikovic +8 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Transfers for ramified covering maps in homology and cohomology
International Journal of Mathematics and Mathematical Sciences, 2006 Making use of a modified version, due to McCord, of the Dold-Thom construction of ordinary homology, we give a simple topological definition of a transfer for ramified covering maps in homology with arbitrary coefficients.
Marcelo A. Aguilar, Carlos Prieto
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
L^2-homology for compact quantum groups
, 2008 A notion of L^2-homology for compact quantum groups is introduced, generalizing the classical notion for countable, discrete groups. If the compact quantum group in question has tracial Haar state, it is possible to define its L^2-Betti numbers and ...
Kyed, David
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source