Results 61 to 70 of about 307,157 (265)
Homological stability of spin mapping class groups and quadratic symplectic groups
Forum of Mathematics, SigmaWe study the homological stability of spin mapping class groups of surfaces and of quadratic symplectic groups using cellular $E_2$ -algebras. We get improvements in their stability results, which for the spin mapping class groups we show to be ...
Ismael Sierra
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FREE FINITE GROUP ACTIONS ON RATIONAL HOMOLOGY 3-SPHERES
Forum of Mathematics, Sigma, 2019 We use methods from the cohomology of groups to describe the finite groups which can act freely and homologically trivially on closed 3-manifolds which are rational homology spheres.
ALEJANDRO ADEM, IAN HAMBLETON
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A limit approach to group homology
Journal of Algebra, 2008 In this paper, we consider for any free presentation $G = F/R$ of a group $G$ the coinvariance $H_{0}(G,R_{ab}^{\otimes n})$ of the $n$-th tensor power of the relation module $R_{ab}$ and show that the homology group $H_{2n}(G,{\mathbb Z})$ may be identified with the limit of the groups $H_{0}(G,R_{ab}^{\otimes n})$, where the limit is taken over the ...
Emmanouil, I., Mikhailov, R.
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Ample Groupoids, Topological Full groups, Algebraic K-theory Spectra and Infinite Loop Spaces
Forum of Mathematics, PiInspired by work of Szymik and Wahl on the homology of Higman–Thompson groups, we establish a general connection between ample groupoids, topological full groups, algebraic K-theory spectra and infinite loop spaces, based on the construction of small ...
Xin Li
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Efficient inference of homologs in large eukaryotic pan-proteomes
BMC Bioinformatics, 2018 Background Identification of homologous genes is fundamental to comparative genomics, functional genomics and phylogenomics. Extensive public homology databases are of great value for investigating homology but need to be continually updated to ...
Siavash Sheikhizadeh Anari +3 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source