Results 71 to 80 of about 539,595 (279)
A limit approach to group homology
Journal of Algebra, 2008 In this paper, we consider for any free presentation $G = F/R$ of a group $G$ the coinvariance $H_{0}(G,R_{ab}^{\otimes n})$ of the $n$-th tensor power of the relation module $R_{ab}$ and show that the homology group $H_{2n}(G,{\mathbb Z})$ may be identified with the limit of the groups $H_{0}(G,R_{ab}^{\otimes n})$, where the limit is taken over the ...
Emmanouil, I., Mikhailov, R.
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Homological stability of spin mapping class groups and quadratic symplectic groups
Forum of Mathematics, SigmaWe study the homological stability of spin mapping class groups of surfaces and of quadratic symplectic groups using cellular $E_2$ -algebras. We get improvements in their stability results, which for the spin mapping class groups we show to be ...
Ismael Sierra
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Homology and Bisimulation of Asynchronous Transition Systems and Petri Nets
, 2013 Homology groups of labelled asynchronous transition systems and Petri nets are introduced. Examples of computing the homology groups are given. It is proved that if labelled asynchronous transition systems are bisimulation equivalent, then they have ...
Husainov, Ahmet A.
core
On a new geometric homology theory
, 2020 In this note we present a new homology theory, we call it geometric homology theory (or GHT for brevity). We prove that the homology groups of GHT are isomorphic to the singular homology groups, which solves a Conjecture of Voronov.
Yu, Hao
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Efficient inference of homologs in large eukaryotic pan-proteomes
BMC Bioinformatics, 2018 Background Identification of homologous genes is fundamental to comparative genomics, functional genomics and phylogenomics. Extensive public homology databases are of great value for investigating homology but need to be continually updated to ...
Siavash Sheikhizadeh Anari +3 more
doaj +1 more source
Cyclic homology and group actions [PDF]
Journal of Geometry and Physics, 2018 v2: final version. To appear in J. Geom. Phys.
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source