Results 71 to 80 of about 307,157 (265)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Existence of acyclic matching and Morse complex on transitive digraphs

AKCE International Journal of Graphs and Combinatorics
For any digraph, there exists a transitive closure. The transitive digraph is a discrete geometric object which has a close relationship with simplicial complex.
Chong Wang, Shiquan Ren
doaj   +1 more source

Persistent Homology applied to location problems

MATEC Web of Conferences, 2018
Different approaches to solve location problems in transport and logistics have been developed in the literature. This article introduces a new approach using the concept of persistent homology which has been proved to be an efficient method in ...
Bennis Driss, Gharib Fouad, Lebbar Ghita
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The triviality of dihedral cohomology for operator algebras

Scientific African
This article delves into algebraic topology, specifically (co)homology theory, which is essential in various mathematical fields. It explores different types of (co)homology groups such as Hochschild, cyclic, reflexive, and dihedral, focusing on dihedral
Samar A.A. Quota, A.H. Noreldeen, O.H. Fathy, W.M. Mahmoud   +3 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

The homotopy groups $\pi_k(\Omega_n(m))$, $k=1,...,n$

Researches in Mathematics
The paper continues the investigation of the spaces of complex-valued perfect splines $\Omega_n(m)$. These spaces were introduced as generalization of the spaces $\Omega_n$, the topology of which has been studied by V.I. Ruban, V.A. Koshcheev, A.M. Pasko.
A.M. Pasko
doaj   +1 more source

Algebraic Structures Based on a Classifying Space of a Compact Lie Group

Abstract and Applied Analysis, 2013
We analyze the algebraic structures based on a classifying space of a compact Lie group. We construct the connected graded free Lie algebra structure by considering the rationally nontrivial indecomposable and decomposable generators of homotopy groups ...
Dae-Woong Lee
doaj   +1 more source

Identification of novel conserved peptide uORF homology groups in Arabidopsis and rice reveals ancient eukaryotic origin of select groups and preferential association with transcription factor-encoding genes

BMC Biology, 2007
Background Upstream open reading frames (uORFs) can mediate translational control over the largest, or major ORF (mORF) in response to starvation, polyamine concentrations, and sucrose concentrations.
Jorgensen Richard A, Hayden Celine A
doaj   +1 more source