Results 91 to 100 of about 305,462 (309)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Topology of Spaces of Polygons [PDF]
, 2011 We study the topology of spaces of polygons in Euclidean space, viewed up to translations. The main results concern the structure of the homology groups and of the cohomology rings of the spaces.
FROMM, VIKTOR
core
Uniformly finite homology and amenable groups [PDF]
, 2015 Uniformly finite homology is a coarse invariant for metric spaces; in particular, it is a quasi-isometry invariant for finitely generated groups. In this article, we study uniformly finite homology of finitely generated amenable groups and prove that it ...
Blank, Matthias, Diana, Francesca
core +1 more source
Cyclic homology and group actions [PDF]
Journal of Geometry and Physics, 2018 v2: final version. To appear in J. Geom. Phys.
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Efficient inference of homologs in large eukaryotic pan-proteomes
BMC Bioinformatics, 2018 Background Identification of homologous genes is fundamental to comparative genomics, functional genomics and phylogenomics. Extensive public homology databases are of great value for investigating homology but need to be continually updated to ...
Siavash Sheikhizadeh Anari +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Fixed points of finite groups acting on generalised Thompson groups [PDF]
, 2010 We study centralisers of finite order automorphisms of the generalised Thompson groups Fn, ? and conjugacy classes of finite sub- groups in finite extensions of Fn, ?. In particular we show that centralisers of finite automorphisms in Fn, ? are either of
Nucinkis, B.E.A. +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Magnus Representation and Homology Cobordism Groups of Homology Cylinders [PDF]
, 2015 A homology cylinder over a compact manifold is a homology cobordism between two copies of the manifold together with a boundary parametrization. We study abelian quotients of the homology cobordism group of homology cylinders. For homology cylinders over
Sakasai Takuya
core