Results 101 to 110 of about 305,462 (309)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Relative homology groups of digital images [PDF]
, 2014 In this paper we are interested in relative homology groups of digital images. Some properties of the Euler characteristics for digital images are given. We also present reduced homology groups for digital images.
Ege O., Ege M.E., Karaca I.
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Existence of acyclic matching and Morse complex on transitive digraphs
AKCE International Journal of Graphs and CombinatoricsFor any digraph, there exists a transitive closure. The transitive digraph is a discrete geometric object which has a close relationship with simplicial complex.
Chong Wang, Shiquan Ren
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Persistent Homology applied to location problems
MATEC Web of Conferences, 2018 Different approaches to solve location problems in transport and logistics have been developed in the literature. This article introduces a new approach using the concept of persistent homology which has been proved to be an efficient method in ...
Bennis Driss, Gharib Fouad, Lebbar Ghita
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The groups G(n,l) as fundamental groups of Seifert fibered homology spheres [PDF]
, 1995 By means of geometric techniques, concerning Seifert fibered homology spheres, we prove that the groups G(n,l), defined by a balanced presentation with n generators and relators, depending on a pair of integers which are odd and coprime, are pairwise non-
GRASSELLI, Luigi
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The triviality of dihedral cohomology for operator algebras
Scientific AfricanThis article delves into algebraic topology, specifically (co)homology theory, which is essential in various mathematical fields. It explores different types of (co)homology groups such as Hochschild, cyclic, reflexive, and dihedral, focusing on dihedral
Samar A.A. Quota +3 more
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Approximation properties for discrete groups [PDF]
, 2006 We give an overview of approximation properties in the context of operator algebras associated with ...
Brodzki, Jacek, Niblo, Graham A.
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