Results 111 to 120 of about 30,354 (250)

Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
Using time‐series transcriptomic profiling of diabetic mouse kidneys, our study reveals substantial circadian disruption in diabetic nephropathy, with significant impacts on protein homeostasis and glycolipid metabolism. Furthermore, our findings highlight the potential influence of circadian system dysregulation on the disorder of fatty acid ...
Xiao‐Qian Li, Lei Cheng, Tian‐Fen Chen, Yi‐Nuo Ma, Lu‐Yao Wang, Xiao‐Hui Li, Ting‐Yu Fu, Jing Xiao, Zhan‐Zheng Zhao   +8 more
wiley   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Corresponding of Genetic polymorphism the apolipoprotein B R3500Q gene mutation with possible Familial Hypercholesterolemia (FH) pateints in Sulaymaniyah

Tikrit Journal of Pure Science, 2019
Familial Hypercholesterolemia (FH) is autosomal codominant disease Characterized by elevated LDL Cholesterol and Early Coronary Artery disease.
Hadeel A. Abdel-Razaak Al-daraji, Akeel H. Ali Al-Assie, Rada H. Hussien   +2 more
doaj   +1 more source

R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study [PDF]

, 2011
Background Heterozygous Familial Hypercholesterolemia (FH) is a genetic disorder characterized by a high risk of cardiovascular disease. Certain polymorphisms of the factor VII gene have been associated with the development of coronary artery disease and
Juan Criado-García, Francisco Fuentes, Cristina Cruz-Teno, Antonio García-Rios, Anabel Jiménez-Morales, Javier Delgado-Lista, Pedro Mata, Rodrigo Alonso, José López-Miranda, Francisco Pérez-Jiménez, null null   +10 more
core   +2 more sources

Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy

Epilepsia, Volume 67, Issue 2, Page 979-992, February 2026.
Abstract Objective Absence epilepsy is characterized by brief but frequent seizures with loss of consciousness. Existing treatments, which come with heavy side effects, are only partially effective and do not address the associated comorbidities, including cognitive and social deficits.
Coline Rulhe, Steeve Thirard, Juri Aparicio Arias, Leila Makrini, Florence Fauvelle, Emmanuelle Beyne, Alexandra Dauvé, Tristan Bouschet, Emmanuel Valjent, Federica Bertaso   +9 more
wiley   +1 more source

Achieving the impossible: effective reduction of low-density lipoprotein cholesterol (LDL-C) in a patient with homozygous familial hypercholesterolemia

Endokrynologia Polska
Not required for Clinical Vignette.
Mateusz Maligłówka, Aleksandra Sojka, Adrianna Dec, Bogusław Okopień, Łukasz Bułdak   +4 more
doaj   +1 more source

Low-density lipoprotein cholesterol lowering therapies: what is on the horizon? [PDF]

, 2015
Elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with an increased risk for cardiovascular disease (CVD). Statins have been the cornerstone of lipid therapy to lower LDL-C for the past two decades, but despite significant ...
Figueredo, M.D., Vincent M, Gadi, Ramprasad   +1 more
core   +1 more source

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease [PDF]

, 2017
Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease models still depend upon laborious germline targeting, and are further complicated by the need to ...
Bao, Gang, Bissig, Karl-Dimiter, Gillard, Baiba K., Gupta, Rajat, Hsu, Rachel H., Jarrett, Kelsey E., Lagor, William R., Lee, Chang Seok, Lee, Ciaran M., Martin, James F., Pownall, Henry J., Rodriguez, Perla J., Yeh, Yi-Hsien, Zhang, Min   +13 more
core   +1 more source

Evaluation of Pathogenic Variants Associated With Monogenic Disorders of Dyslipidemia in Patients With Well Characterised MASLD

Liver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background and Aims Dyslipidemia is common in patients with MASLD, but the frequency and significance of inherited disorders of dyslipidemia are unclear. We investigated the prevalence and significance of pathogenic variants associated with selected monogenic disorders of dyslipidemia in 3358 patients with well‐characterised MASLD. Approach We
Tae‐Hwi Schwantes‐An, Marco A. Abreu, Brent A. Neuschwander‐Tetri, Jian Wang, Xiuqing Guo, Jingyi Tan, Robert A. Hegele, Nicholas O. Davidson, Luca Lotta, Niek Verweij, Katherine P. Yates, Jerome I. Rotter, Naga Chalasani   +12 more
wiley   +1 more source

[Homozygous familial hypercholesterolemia].

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2015
Familial hypercholesterolemia (FH) is caused by genetic deficiency of LDL receptors leading to extremely high cholesterol levels and atherosclerosis at early ages. For the prevention of early atherosclerotic cardiovascular events, effective reduction of LDL-cholesterol is necessary from the early ages. However, particularly in homozygous patients, it's
openaire   +3 more sources