Results 91 to 100 of about 286,443 (160)

The effect of lomitapide on cardiovascular outcome measures in homozygous familial hypercholesterolemia: A modelling analysis

, 2017
Background Patients with homozygous familial hypercholesterolemia are at high risk of cardiovascular disease due to high low-density lipoprotein (LDL)-cholesterol levels. Cardiovascular disease outcome studies are impossible to conduct, due to the rarity
Leipold, Robert, Ishak, Jack, Phillips, Helen, Raal, Frederick, Hovingh, Kees   +4 more
core   +1 more source

Mipomersen and other therapies for the treatment of severe familial hypercholesterolemia

Vascular Health and Risk Management, 2012
Damon A Bell,1–3 Amanda J Hooper,1,2,4 Gerald F Watts,2,3 John R Burnett1–41Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, 2School of Medicine and Pharmacology, 3Lipid Disorders Clinic ...
Bell DA, Hooper AJ, Watts GF, Burnett JR
doaj  

Coronary artery bypass grafting in a 14-year-old boy with compound heterozygous LDLR familial hypercholesterolemia: a case report

Frontiers in Pediatrics
Familial hypercholesterolemia (FH), particularly homozygous or compound heterozygous forms, predisposes individuals to premature cardiovascular disease due to severely elevated low-density lipoprotein cholesterol (LDL-C).
Ke Zhu, Fuqiang Zhang, Jin Wang, Chunjing Li   +3 more
doaj   +1 more source

Mortality Among Patients With Familial Hypercholesterolemia: A Registry‐Based Study in Norway, 1992–2010

, 2014
Background Untreated patients with familial hypercholesterolemia are at increased risk of premature cardiovascular death. The primary aim of this study was to investigate whether this is also the case in the statin era.
Retterstøl, Kjetil, Veierød, Marit B., Mundal, Liv, Leren, Trond P., Iversen, Per Ole, Ose, Leiv, Borgan, Jens‐Kristian, Sarancic, Mirza   +7 more
core   +1 more source

Breaking barriers: Innovative therapies for managing homozygous familial hypercholesterolemia

Experimental and Molecular Pathology
Homozygous familial hypercholesterolemia (HoFH) is a rare autosomal recessive disorder characterized by variants in genes involved in the regulation of low-density lipoprotein cholesterol (LDL-C) metabolism.
Shuai-Jie Huang, Ping Huang, Nan-Nan Song, Xian-Hui Jia, Hong-Li Gao, Zhi-Yuan Lu, Xiao-Lan Wen   +6 more
doaj   +1 more source

Homozygous familial hypercholesterolemia (HoFH) in Germany: an epidemiological survey

ClinicoEconomics and Outcomes Research, 2013
S Walzer,1 K Travers,2 S Rieder,3 E Erazo-Fischer,3 D Matusiewicz41MArS Market Access and Pricing Strategy UG (hb), Weil am Rhein, Germany; 2United Biosource Corporation, Lexington, USA; 3Alcimed GmbH, Cologne, Germany; 4Institute for Health Care ...
Walzer S, Travers K, Rieder S, Erazo-Fischer E, Matusiewicz D   +4 more
doaj  

Liver transplantation in severe and homozygous familial hypercholesterolemia - a scoping review

The purpose of this scoping review will be to examine the existing literature surrounding liver transplantation in patients with homozygous familial hypercholesterolemia (hoFH)
Erin Kelty, Jing Pang
core   +1 more source

Lomitapide in homozygous familial hypercholesterolemia: cardiology perspective from a single-center experience

, 2018
AIMS: Homozygous familial hypercholesterolemia (HoFH) is a genetic dyslipidemia characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and accelerated atherosclerosis.
Gragnano F, Sperlongano, Rossella, Russo, Maria giovanna, Marcello Arca, Arca M, D'Erasmo L, D'Erasmo, Laura, Calabrò P, Gragnano, Felice, Golia E, Giuseppe Limongelli, Russo M, Mario Crisci, Laura D’Erasmo, Natale F, Enrica Golia, Natale, Francesco, Concilio C, Simona Sperlongano, Rossella Sperlongano, Fabio Fimiani, Calabrò, Paolo, Limongelli G, Arca, Marcello, Cesaro A, Fimiani, Fabio, Cesaro, Arturo, Crisci M, Crisci, Mario, Golia, Enrica, Paolo Calabrò, Sperlongano R, Mariagiovanna Russo, Sperlongano S, Arturo Cesaro, Fimiani F, Claudia Concilio, Francesco Natale, Limongelli, Giuseppe, Concilio, Claudia, Sperlongano, Simona, Felice Gragnano   +41 more
core   +1 more source

Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia

, 2013
Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or ...
TÜMER, LEYLA, Kasapkara, ÇİĞDEM SEHER, Hasanoglu, Alev, Demirtas, CANAN, ÇELİK, BÜLENT, Dilsiz, Gunter, Pasaoglu, Ozge, EZGÜ, FATİH SÜHEYL, Yenicesu, Idil, Kucukcongar, Aynur   +9 more
core   +1 more source

[Clinico-pathological evaluation of patients with homozygous familial hypercholesterolemia].

, 1991
The authors have studied 8 patients with Homozygous Familial Hypercholesterolemia (FHO) an autosomal genetic dominant disease due to mutation of the gene encoding a cell surface receptor for LDL.
NAPOLI, Claudio, Calì A., Di Gregorio F, D'ARMIENTO, FRANCESCO PAOLO, Napoli C, Posca T, D'ARMIENTO FP, Colasanti P   +7 more
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