Results 11 to 20 of about 30,354 (250)

Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia [PDF]

JACC: Case Reports
We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age.
Hayato Tada, MD, Hirofumi Okada, MD, Masa-aki Kawashiri, MD, Masayuki Takamura, MD   +3 more
doaj   +3 more sources

Homozygous Familial Hypercholesterolemia

Journal of Atherosclerosis and Thrombosis, 2021
Familial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH ...
Nohara, Atsushi, Tada, Hayato, Ogura, Masatsune, Okazaki, Sachiko, Ono, Koh, Shimano, Hitoshi, Daida, Hiroyuki, Dobashi, Kazushige, Hayashi, Toshio, Hori, Mika, Matsuki, Kota, Minamino, Tetsuo, Yokoyama, Shinji, Harada-Shiba, Mariko   +13 more
openaire   +4 more sources

Current Treatment Options in Homozygous Familial Hypercholesterolemia

Pharmaceuticals, 2022
Homozygous familial hypercholesterolemia (HoFH) is the rare form of familial hypercholesterolemia causing extremely high low-density lipoprotein cholesterol (LDL-C) levels, leading to atherosclerotic cardiovascular disease (ASCVD) in the first decades of
Meral Kayikcioglu, Lale Tokgozoglu
doaj   +2 more sources

Marked plaque regression in homozygous familial hypercholesterolemia [PDF]

Atherosclerosis, 2021
Both plasma low-density lipoprotein (LDL) cholesterol levels and risk for premature cardiovascular disease are extremely elevated in patients with homozygous familial hypercholesterolemia (HoFH), despite the use of multiple cholesterol lowering treatments.
Laurens F. Reeskamp, Nick S. Nurmohamed, Michiel J. Bom, R. Nils Planken, Roel S. Driessen, Pepijn A. van Diemen, Ilse K. Luirink, Jaap W. Groothoff, Irene M. Kuipers, Paul Knaapen, Erik S.G. Stroes, Albert Wiegman, G. Kees Hovingh   +12 more
openaire   +4 more sources

New algorithms for treating homozygous familial hypercholesterolemia

Current Opinion in Lipidology, 2022
Purpose of review We reviewed current and future therapeutic options for patients with homozygous familial hypercholesterolemia (HoFH) and place this evidence in context of an adaptable treatment algorithm. Recent findings Lowering LDL-C levels to normal in patients with HoFH is ...
Tromp, Tycho R., Cuchel, Marina
openaire   +4 more sources

Case Report: Beating the assumed prognosis: homozygous familial hypercholesterolemia with unexpected long survival [PDF]

Frontiers in Cardiovascular Medicine
BackgroundFamilial hypercholesterolemia (FH) is a common autosomal codominant genetic disorder, with heterozygous FH (HeFH) affecting approximately 1 in 310 individuals.
Lukáš Zlatohlávek, Jana Becherová Beňová, Tereza Foglarová, Tereza Dudková, Jaroslav A. Hubáček, Jaroslav A. Hubáček   +5 more
doaj   +2 more sources

Homozygous Familial Hypercholesterolemia

JACC: Case Reports, 2022
This case report describes a 67-year-old African-American woman with homozygous familial hypercholesterolemia caused by 2 pathogenic variants in the LDLR gene.
Lisa Young, Emily E. Brown, Seth S. Martin   +2 more
semanticscholar   +3 more sources

Homozygous Familial Hypercholesterolemia

JACC: Advances, 2023
Corresponding ...
F. Raal
semanticscholar   +5 more sources

The High Price of Interrupted Follow-Up: Catastrophic Progression of Homozygous Familial Hypercholesterolemia-A Case Report and Literature Review. [PDF]

Clin Case Rep
ABSTRACT Familial hypercholesterolemia (FH) is the most common monogenic lipid disorder, primarily resulting from mutations in LDLR, APOB, and PCSK9 genes. These mutations cause persistently high levels of low‐density lipoprotein cholesterol (LDL‐C), predisposing affected individuals to premature atherosclerotic cardiovascular disease (ASCVD ...
Dastjerdi P, Aghababaei M, Nikfar R, Aghakouchakzadeh M, Mohseni-Badalabadi R, Hosseini K.   +5 more
europepmc   +2 more sources

Intertriginous Xanthomas: Clues to Homozygous Familial Hypercholesterolemia [PDF]

Indian Dermatology Online Journal
Nikhil Mehta, Gouri Anand, Anamika Choudhary, Somesh Gupta   +3 more
doaj   +2 more sources