Results 41 to 50 of about 4,203,369 (355)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Digital Advertising in U.S. Federal Elections, 2004-2020
Journal of Quantitative Description: Digital Media, 2022 Digital advertising is now a commonplace feature of political communication in the United States. Previous research has documented the key innovations associated with digital political advertising and its consequences for campaigns and elections ...
Adam Sheingate +2 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Shakespeare and Language [PDF]
, 2010 Written by a team of leading international scholars, this Companion is designed to illuminate Shakespeare's works through discussion of the key topics of Shakespeare studies.
Hope, Jonathan
core
Issuance of the Keystone XL Permit: Presidential Prerogative or Presidential “Chutzpah” [PDF]
, 2020 This article uses President Trump\u27s issuance of the Keystone XL Pipeline permit to illustrate the dangers of an imperial presidency, one in which the exercise of discretionary authority, based on neither the text of Article II of the Constitution nor ...
Babcock, Hope M.
core +2 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
, 2010 The world's greatest playwright is as alive today as he was 400 years ago. His works reflect the political and domestic concerns of contemporary society and are read widely by students, adapted into lavish films, and staged in stunning new productions ...
Hope, Jonathan
core
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
The Oncologist, 2007 Learning ObjectivesAfter completing this course, the reader will be able to: Describe the powerful dynamic of hope for patients with cancer.Discuss the importance of addressing how issues of life and death affect patients, families, and caregivers.List the advantages and limitations of realistic hopefulness.Better care for and communicate with patients
Richard T, Penson +6 more
openaire +2 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source