Results 71 to 80 of about 4,250,793 (306)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

The need for support: Young people living through a family health crisis [PDF]

open access: yes, 2017
Young people living with a family health crisis are found to experience high levels of distress, anxiety, low mood and depressive symptoms and are at risk of becoming disengaged with education, socially isolated and uncertain regarding what the future ...
Bennett, Stephanie   +2 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Illegal Marijuana Cultivation on Public Lands: Our Federalism on a Very Bad Trip [PDF]

open access: yes, 2017
Fueled by increasing demand for marijuana, illegal cultivation of the drug on public lands is causing massive environmental harm. The federal government lacks the resources to wage what would be a difficult and costly campaign to eradicate these illegal ...
Babcock, Hope M.
core   +1 more source

Historical geography III: hope persists [PDF]

open access: yes, 2019
The final report in this series focuses on the emerging intersections between historical geography, archaeology and the law. Whilst staying attuned to the darkest of geographies emerging from the sub-field, this report turns its attention to the ...
McGeachan, Cheryl
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

The platformisation of party politics?

open access: yesJournal of Quantitative Description: Digital Media
Political parties have gone digital. Political scientists in countries around the world have diagnosed the rise of the digital party and traced parties’ adoption of digital technology.
Kate Dommett   +2 more
doaj   +1 more source

The Sad Story of the Northern Rocky Mountain Gray Wolf Reintroduction Program [PDF]

open access: yes, 2013
A reflection on the past, present and future of environmental law in this 20th Anniversary Edition offers an opportunity to revisit the Endangered Species Act, particularly the Northern Rocky Mountain States federal wolf reintroduction program ...
Babcock, Hope M.
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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