Results 31 to 40 of about 1,329,986 (279)

The Kraken in the Aquarium: questions that urgently need to be addressed in order to advance marine conservation

Frontiers in Marine Science, 2016
Despite advances in marine conservation research, policy, and management, human activities continue to negatively affect marine species, habitats, and ecosystems, and the people who rely on them for needed resources.
John A. Cigliano, John A. Cigliano, Amy Bauer, Megan M. Draheim, Melissa Foley, Carolyn J. Lundquist, Carolyn J. Lundquist, Julie-Beth McCarthy, Katheryn W. Patterson, Andrew J. Wright, E.C.M. Parsons   +10 more
doaj   +1 more source

Environmental crime and the harm prevention criminalist

Frontiers in Conservation Science, 2022
The role of the ‘pracademic’ comes in the fore in the interface between academia and environmental protection. This article explores the translation of evidence-based research and theoretical innovation in environmental crime prevention into ground level
Rob White
doaj   +1 more source

Scanning the horizon: deep mutational scanning approaches in virology

Journal of Virology
Studying the effects of mutations is central to virology. Deep mutational scanning (DMS) is a technique that couples high-throughput mutagenesis with deep sequencing to measure the effects of mutations in pooled assays.
Jack Dorman, William Bakhache, Patrick T. Dolan   +2 more
doaj   +1 more source

FINANCIAL AND INVESTMENT PREDICATES OF SECURITY OF HOTEL REAL ESTATE DEVELOPMENT

Фінансово-кредитна діяльність: проблеми теорії та практики, 2022
The article examines the level of safety of investments in hotel real estate, and also develops general recommendations regarding its provision. It is noted that the safety of investments is an integral concept, and its achievement of optimal indicators
Анатолій Мазаракі, Світлана Мельниченко, Людмила Бовш, Тетяна Ткачук, Наталія Зікій, Людмила Романчук   +5 more
doaj   +1 more source

Health horizons: Future trends and technologies from the European Medicines Agency’s horizon scanning collaborations

Frontiers in Medicine, 2022
In medicines development, the progress in science and technology is accelerating. Awareness of these developments and their associated challenges and opportunities is essential for medicines regulators and others to translate them into benefits for ...
Valentina Vignali, Valentina Vignali, Philip A. Hines, Philip A. Hines, Ana Glória Cruz, Barbara Ziętek, Ralf Herold   +6 more
doaj   +1 more source

Exploring the Problem of Establishing Horizon Emergent Technologies within a Higher Education Institution’s Operational Framework

EURODL, 2020
Since the early 2000s, a plethora of web-based learning technologies has been developed, each proposing to improve the student experience. Yet, a study conducted by Martin et al. (2018) demonstrate sporadic new technology adoption in Higher Education (HE)
Paula Shaw, Sarah Rawlinson, David Sheffield   +2 more
doaj   +1 more source

Innovation toolkit a practical guide: Introduction to horizon scanning in the public sector [PDF]

, 2014
Horizon scanning is a structured process designed to capture, make sense of and assess the importance of emerging issues, trends and developments in train – that are often not very obvious today – and that might significantly influence current policy ...
Kate Delaney
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source