Results 41 to 50 of about 1,329,986 (279)

Horizon scanning for pharmaceuticals [PDF]

, 2017
TABLE OF CONTENTS 1 -- LIST OF FIGURES 5 -- LIST OF TABLES 6 -- LIST OF ABBREVIATIONS 8 -- SCIENTIFIC REPORT 12 -- 1 SCOPE AND OBJECTIVES OF THE STUDY 12 -- 2 WHAT IS A HORIZON SCANNING SYSTEM? 13 -- 3 METHODS 17 -- 3.1 INTERNATIONAL COMPARISON 17 -- 3.1.1 Data collection 17 -- 3.1.2 Data analysis 18 -- 3.2 DEVELOPMENT OF A PROPOSAL FOR A JOINT HSS 18 -
Lepage-Nefkens, Isabelle, Douw, Karla, Mantjes, Gertjan, de Graaf, Gimon, Leroy, Roos, Cleemput, Irina   +5 more
openaire   +3 more sources

Horizon scanning: bringing strategic insight to national security policymaking [PDF]

, 2012
The Australian Government has recently undertaken a number of concrete initiatives to enhance national security policy coordination. As of the date of publication of this paper, some have been implemented, such as the ‘All Hazards National Assessment’ on
David Connery
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The Early Awareness and Alert System in Sweden: History and Current Status

Frontiers in Pharmacology, 2017
Introduction: Over the past decades, early awareness and alert (EAA) activities and systems have gained importance and become a key early health technology assessment (HTA) tool.
Irene Eriksson, Irene Eriksson, Björn Wettermark, Björn Wettermark, Marie Persson, Morgan Edström, Brian Godman, Brian Godman, Brian Godman, Anna Lindhé, Rickard E. Malmström, Rickard E. Malmström, Helena Ramström, Mia von Euler, Mia von Euler, Mia von Euler, Anna Bergkvist Christensen   +16 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Scientists’ perspectives on global ocean research priorities

Frontiers in Marine Science, 2014
Diverse natural and social science research is needed to support policies to recover and sustain healthy oceans. While a wide variety of expert-led prioritization initiatives have identified research themes and priorities at national and regional scale ...
Murray Alan Rudd
doaj   +1 more source

Identifying the science and technology dimensions of emerging public policy issues through horizon scanning [PDF]

, 2014
Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development.
Sarah Castell, David Oxenham, Heathfield, Adam, Tim Leeder, Sutherland, William J, Heathfield, A., Dolan, James A, Neilson, Ross, Worts, Kim, Alan Mercer, Wentworth, Jonny, Stansfield Neil, Wollner, Patrick K. A., Guilliams Tim T., Pratt Alan, Ross Neilson, Good David A., Mata Tiago, Lickorish, F.A., Feng, Wai Yi, Castell Sarah, Mercer, Alan, Pinkerton, Jan, Sutherland William J., Cope David, Ouchikh, J., Bland, Jessica, Good, David A, Mata, T., Cleevely, David D, Grant, J., Doubleday, Robert, Godfray, H Charles J, Armstrong Harry J., Neil Stansfield, Pratt, Alan, Worts Kim, Kass, G., Surkovic Elizabeth, Tony McBride, Wollner, P.K.A., Jackie Ouchikh, Ploszek Richard, Helen C Bodmer, Surkovic, Elizabeth, Chilvers Jason, Bodmer, Helen C., Hall, Amanda C., Ploszek, R., Gary Kass, Magee Chris, Pallett, H., Watkinson Andrew R., Burall Simon, Oughton, E.J., Hall Amanda C., Hall, Amanda C, Godfray H. Charles J., Neilson Ross, Lickorish, Fiona A., Ploszek, Richard, Armstrong, Harry J., Parker, Miles, Guilliams, Tim T., Wollner, Patrick K A, Godfray, H. Charles J., Tyler, Christopher P., Bellingham Jim R., Andrew Acland, Miles Parker, Armstrong, A.J., Magee, Chris, Andrew R Watkinson, David D Cleevely, Bellingham, J.R., Wentworth Jonny, Oughton Edward J., Sunjai Gupta, Burrall, S., Guilliams, Tim T, Oughton, Edward J, Acland, Andrew, Rebecca Willis, Watkinson, A.R., Burall, Simon, Castell, Sarah, Leader, T., James Palmer, Parker, M., Guilliams, T.T., Kim Worts, Palmer James, Hotopp, U., McBride, T., Gupta, S., Tyler, C.P., Stansfield, N., Lickorish Fiona A., Doubleday Robert, Rocks Sophie A., Oxenham, David, Mercer, A., Patmore, Jeff, McCarthy, N., Mercer Alan, Lickorish, Fiona A, Jonny Wentworth, Ouchikh Jackie, Jeff Patmore, Dolan James A., Willis Rebecca, Patmore, J., Patrick K A Wollner, Helen Pallett, Sutherland, William J., Christopher P Tyler, Godray, H.C.J., Leila M Lueshi, Lueshi, L.M., Armstrong, Harry J, Ouchikh, Jackie, Bland Jessica, Lueshi, Leila M., McBride, Tony, Tiago Mata, McCarthy, Natasha, Arnoud J Groen, Costanzo Lucia, Castell, S., Pallett, Helen, Palmer, J., Watkinson, Andrew R, Constanzo, L., Pratt, A., Feng, W.Y, Bellingham, Jim R, Rocks, S.A., Rocks, Sophie A, Dolan, James A., Surkovic, E., Good, D.A., James A Dolan, Judith Petts, Oxenham, D., Bodmer, Helen C, McCarthy Natasha, Cope, David, Alan Pratt, Groen, Arnoud J., Cleevely David D., Jim R Bellingham, Sophie A Rocks, Jessica Bland, Feng Wai Yi, Leeder Tim, Bellingham, Jim R., Groen Arnoud J., Doubleday, R., Hotopp, Ulrike, Stansfield, Neil, Simon Burall, Tim T Guilliams, Hotopp Ulrike, Tyler Christopher P., Good, David A., Leeder, Tim, Parker Miles, Lucia Costanzo, Wollner Patrick K. A., Cope, D., Jonathan Grant, Pinkerton Jan, Palmer, James, Bodmer, H.C, Gupta, Sunjai, Watkinson, Andrew R., Lueshi Leila M., Jan Pinkerton, Bland, J., Grant Jonathan, Edward J Oughton, Bodmer Helen C., Acland Andrew, Worts, K., Adam Heathfield, Green, Nick, Willis, Rebecca, Wollner, Patrick K.A., Heathfield Adam, Nick Green, Grant, Jonathan, Green Nick, Dolan, J.A., H Charles J Godfray, Hall, A.C., Acland, A., Natasha McCarthy, Wentworth, J., Willis, R., Groen, A.J., Petts Judith, Fiona A Lickorish, Lueshi, Leila M, Jason Chilvers, Pinkerton, J., Kass Gary, Cleevely, D.D., Harry J Armstrong, Oughton, Edward J., Ulrike Hotopp, Richard Ploszek, Cleevely, David D., Wai Yi Feng, Pallett Helen, Oxenham David, Chilvers, J., William J Sutherland, Sutherland, W.J., Robert Doubleday, Magee, C., McBride Tony, Petts, Judith, Gupta Sunjai, Tyler, Christopher P, Chris Magee, Patmore Jeff, Groen, Arnoud J, Green, N., Nielson, R., Chilvers, Jason, Amanda C Hall, Mata, Tiago, Rocks, Sophie A., Kass, Gary, Elizabeth Surkovic, Costanzo, Lucia, David A Good, David Cope   +237 more
core   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source