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Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [PDF]

open access: yesEndocrines
GHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanisms mediating ...
Saikat Fakir, Nektarios Barabutis
doaj   +2 more sources

Gonadotropin-Releasing Hormone Antagonists-A New Hope in Endometriosis Treatment? [PDF]

open access: goldJ Clin Med, 2023
Rzewuska AM   +7 more
europepmc   +3 more sources

Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

open access: yesNeural Regeneration Research, 2022
Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen   +3 more
doaj   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

open access: yes, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér   +6 more
core   +13 more sources

Androgen deprivation therapy and side effects: are GnRH antagonists safer?

open access: yesAsian Journal of Andrology, 2021
Androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonists and antagonists is the mainstay of advanced prostate cancer treatment. Both drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones (FSH),
Stephen J Freedland   +1 more
doaj   +1 more source

Impact of Androgen Deprivation Therapy on Cardiovascular Outcomes in Prostate Cancer

open access: yesSociété Internationale d’Urologie Journal, 2022
PurposeSubstantial evidence indicates that men with prostate cancer are at an increased risk for cardiovascular disease, and medical and surgical androgen deprivation therapy is associated with further increased cardiovascular risk. There are conflicting
Laurence Klotz   +3 more
doaj   +1 more source

Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine

open access: yesF&S Reports, 2023
Gonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production.
Farrah L. Saleh, M.D.   +1 more
doaj   +1 more source

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