Results 261 to 270 of about 136,105 (353)

The role of gonadotrophin-releasing hormone antagonists in the treatment of patients with advanced hormone-dependent prostate cancer in the UK. [PDF]

World J Urol, 2016
Rosario DJ, Davey P, Green J, Greene D, Turner B, Payne H, Kirby M.   +6 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Emerging Medical Therapies for Primary Aldosteronism. [PDF]

Hypertension
Vibhatavata P, Turcu AF.
europepmc   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

Advanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang   +22 more
wiley   +1 more source

From Mechanism to Medicine: Peptide-Based Approaches for Cancer Diagnosis and Therapy. [PDF]

Biomolecules
Gouveia MJ, Campanhã J, Barbosa F, Vale N.   +3 more
europepmc   +1 more source

Vasopressin receptor antagonist in the treatment of the syndrome of inappropriate antidiuretic hormone in general hospital practice

, 2012
Rajesh Rajendran, Ashley Grossman, Partha Kar   +2 more
openalex   +2 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Cost-effectiveness analysis of second-generation androgen receptor antagonists for the treatment of metastatic hormone-sensitive prostate cancer. [PDF]

Front Public Health
Yang Y, Chen YQ, Huang LZ, Chen Y.
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Androgen receptor activation promotes tumor progression in canine and human triple negative breast cancer cell lines. [PDF]

Front Vet Sci
Caceres S, Crespo B, Herrera M, de la Puente M, Diaz Del Arco C, Alonso-Diez A, Illera MJ, Illera JC.   +7 more
europepmc   +1 more source