Results 101 to 110 of about 125,967 (307)

Thyroid hormone replacement therapy in dialysis/renal insufficiency patients

Frontiers in Endocrinology
Dialysis/renal insufficiency patients are often accompanied by hypothyroidism due to renal damage, the mechanisms of which are complex. The use of thyroid hormone replacement therapy in such patients has become an important clinical issue.
Xiaolu Zhao, Fan Liu, Saiya Yuan, Fei Wang, Chunyu Li, Congcong Guo, Junyu Zhao   +6 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women

, 1998
To compare the effects on body composition and body weight of tibolone vs two different sequential oral or transdermal oestrogen-progestogen hormone replacement therapies versus no ...
Jaeger, P, Birkhäuser, M H, Kurt Lippuner, Fritz F. Horber, Horber, F F, Martin H. Birkhäuser, Willy Hänggi, Philippe Jaeger, Hänggi, W, Lippuner, K   +9 more
core   +1 more source

Current aspects of hormone replacement therapy application for cardiac embarrassment correction in women with climacteric syndrome

RUDN Journal of Medicine, 2008
Hormone replacement therapy (HRT) has been widely used for reliving climacteric disorders. The purpose of present study is to evaluate myocardium function in case of HRT application.
A M Popkova, O V Kaysina, A V Godulayn, V A Dudaev, S A Popkov, V E Dvornikov   +5 more
doaj  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Hormone replacement therapy

, 2005
These three booklets offer information and advice to health professionals and to consumers about the use of hormone replacement therapy (HRT). Hormone Replacement Therapy: A Summary of the Evidence for General Practitioners and other Heath Professionals

core  

Thyroid hormone replacement one day before 131I therapy in patients with well-differentiated thyroid cancer [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2013
Objective: The current study aimed to determine the efficacy of radioiodine-131 (131I) ablation therapy with thyroid hormone replacement one day before 131I administration in patients with well-differentiated thyroid cancer (DTC).
Daiki Kayano, Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ayane Nakamura, Makoto Fukuoka, Seigo Kinuya   +6 more
doaj  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Italian position statement on hormone replacement therapy following the National Conference on Menopause and Hormone Replacement Therapy

, 2007
Italian position statement on hormone replacement therapy following the National Conference on Menopause and Hormone Replacement Therapy, Villa Tuscolana, Frascati (Rome), May 8-9 ...
BECORPI, A. M., MELIS, G. B., GENNAZZANI, A. R., TADDEI, S., PETRAGLIA, F., TONELLI, F., ANNIVERNO, R., Simoncini, Tommaso, LELLO, S., SISMONDI, P., Genazzani, Andrea Ricardo, NAPPI, C., NAPPI, R. E., Gambacciani, Marco, BIGLIA, N., SERRA, G. B., MASSOBRIO, M., BRANDI, M. L., GAMBACCIANI, M., MENCACCI, C., ROSANO, G. M., GUASCHINO, S., MODENA, M. G., SIMONCINI, T., PECORELLI, S.   +24 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source