Results 1 to 10 of about 2,263,747 (429)

Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway

open access: yesJournal of Diabetes Research, 2022
Aim. Patients with diabetic ketosis often exhibit albuminuria. We previously found that acute hyperglycaemia can cause nephrotoxic injury. Here, we explored whether an excessive ketone body level causes kidney injury and the potential underlying ...
Minxia Zuo   +10 more
doaj   +1 more source

Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles

open access: yesBMC Cancer, 2022
Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and targeting moieties could improve the therapeutic delivery of anti-cancer drugs.
Ahmed A. Abd-Rabou   +2 more
doaj   +1 more source

Identification of SRS transcription factor family in Solanum lycopersicum, and functional characterization of their responses to hormones and abiotic stresses

open access: yesBMC Plant Biology, 2023
The SHI RELATED SEQUENCE (SRS) family plays a vital role in the development of multiple plant organs such as floral meristem determinacy, organ morphogenesis, and signal transduction.
Wang Lu   +10 more
doaj   +1 more source

The targeted delivery of chitosan nanoparticles to treat indoxacarb: induced lung fibrosis in rats

open access: yesBulletin of the National Research Centre, 2022
Background This study evaluated the effects of chitosan nanoparticles (Ch-NPs) on indoxacarb (INDOX)-induced pulmonary fibrosis in in vivo and in vitro models. In in vivo studies, 40 male albino rats were randomly divided into four groups (10 rats/group):
Naglaa A. Ali   +3 more
doaj   +1 more source

Genome-wide identification, characterization and expression analysis of BES1 gene family in tomato

open access: yesBMC Plant Biology, 2021
Background As the key regulators in BR signaling, BES1 family genes regulate thousands of target genes involved in various development processes. So far, the functions of BES1 family are poorly understood in tomato, and a comprehensive genomic and ...
Deding Su   +6 more
doaj   +1 more source

Roles of Auxin in the Growth, Development, and Stress Tolerance of Horticultural Plants

open access: yesCells, 2022
Auxin, a plant hormone, regulates virtually every aspect of plant growth and development. Many current studies on auxin focus on the model plant Arabidopsis thaliana, or on field crops, such as rice and wheat.
Qiongdan Zhang   +4 more
doaj   +1 more source

Influence of Light-Emitting Diode-Derived Blue Light Overexposure on Rat Ocular Surface

open access: yesJournal of Ophthalmology, 2023
We aim to investigate the effect of overexposure to blue light on the rat ocular surface and explore the potential mechanisms. 450 nm light-emitting diode (LED) derived light at 1000 lux was used to irradiate SD rats, 12 hours a day, for consecutive 28 ...
Li Nan   +5 more
doaj   +1 more source

HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响

open access: yesJournal of Diabetes, 2023
Background Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus ...
Junmei Wang   +6 more
doaj   +1 more source

Basal Glucose Control in Type 1 Diabetes using Deep Reinforcement Learning: An In Silico Validation [PDF]

open access: yesIEEE journal of biomedical and health informatics 2020, 2020
People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the ...
arxiv   +1 more source

False hyperthyroidism caused by interference in immunoassays

open access: yesAdvances in Laboratory Medicine, 2020
Immunoassays used to assess thyroid function are vulnerable to different types of interference that may affect clinical decision-making.
Jiménez García Clara   +5 more
doaj   +1 more source

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