Results 91 to 100 of about 713,905 (310)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

DEMAND FOR BEEF FROM CATTLE ADMINISTERED GROWTH HORMONES OR FED GENETICALLY MODIFIED CORN: A COMPARISON OF CONSUMERS IN FRANCE, GERMANY, THE UNITED KINGDOM, AND THE UNITED STATES [PDF]

This study compares consumer valuations of beef steaks from cattle produced without growth hormones or genetically modified corn in France, Germany, the United Kingdom, and the United States.
Roosen, Jutta, Fox, John A., Lusk, Jayson L.   +2 more
core  

Sex hormones and hypertension [PDF]

, 2002
Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian ...
Oparil, Suzanne, Dubey, Raghvendra K; https://orcid.org/, Jackson, Edwin K, Imthurn, Bruno   +3 more
core   +1 more source

Correlation between newborn weight and serum BCAAs in pregnant women with diabetes

Nutrition & Diabetes
Background Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for mammals. Maternal BCAAs during pregnancy have been associated with newborn development. Meanwhile, BCAAs have been tightly linked with
Na Tang, Yajin Liu, Sa Yang, Mengyu Zhong, Dongqing Cui, Ou Chai, Yurong Wang, Yunwei Liu, Xuejiao Zhang, Zhimin Hou, Haipeng Sun   +10 more
doaj   +1 more source

Cathepsin D in Breast Cancer Tissue

The International Journal of Biological Markers, 1990
The cathepsin D concentration in 18 women with benign breast pathology has a cut-off value of 43 pmol/mg of protein. High values have been detected in two cases of chronic mastitis.
P. Gonzalez Gancedo, M.L. G-Casaus, J. Ruiz Cacho, F. Calero, J.M. Inocente, F. Gomez-Pastrana, N. Ramon   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The role of hormones in wound-stress response in Arabidopsis thaliana

, 2004
Wounding stress is a continuous threat to the survival of all organisms, and, in crop plants it leads to a dramatic reduction in crop yield. The signaling pathways that allow plants to respond to wounding stress are known to be complex.
David, Lisa Illene
core  

Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies

, 2008
Background: Sex hormones in serum have been hypothesized to influence the risk of prostate cancer. We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more ...
Roddam, AW, Key, TJ, Holly, Jeffrey M P, Donovan, Jenny L, Allen, NE, Appleby, P, Endogenous Hormones & Prostate Cancer Collaborative, Group   +6 more
core   +2 more sources