Results 71 to 80 of about 635,629 (317)
Estimating Chronic Exposure to Steroid Hormones in Water
, 2009 Ecological risk assessment (ERA) is a useful process contributing to safeguarding the earth’s ecosystems. Exposure assessment is a vital component of ERAs, as chemical exposure information is used to make decisions involving ecological risk.
Hirons, Natalie Lianne
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The organisational effects of adolescent gonadal hormones on behavioural development in rats
, 2015 Gonadal steroid hormones play an important role in adolescent neural and behavioural development, causing changes that can be seen throughout life. Endogenous hormones have a direct impact on behaviour in both immediate and permanent ways by acting on ...
Kulbarsh, Kyle D.
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Cell Reports MedicineSummary: Confronting oxytocin and vasopressin deficits in autism spectrum disorders and rare syndromes brought promises and disappointments for the treatment of social disabilities.
Amélie M. Borie +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders
Neural Plasticity, 2016 The brain evolved cellular mechanisms for adapting synaptic function to energy supply. This is particularly evident when homeostasis is challenged by stress.
Freddy Jeanneteau +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The role of hormones in wound-stress response in Arabidopsis thaliana
, 2004 Wounding stress is a continuous threat to the survival of all organisms, and, in crop plants it leads to a dramatic reduction in crop yield. The signaling pathways that allow plants to respond to wounding stress are known to be complex.
David, Lisa Illene
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The BES1/BZR1 transcriptional factor SlBES2 regulates photosynthetic apparatus in tomato fruit
BMC Plant BiologyBackground Fruit photosynthetic apparatus development comprises a series of biological processes which is essential in determining fruit development and quality formation.
Ming Huang +5 more
doaj +1 more source