Results 91 to 100 of about 568,795 (313)

Hospital-Acquired Anemia in Patients With Cardiovascular Disease: Incidence, Outcomes, and Opportunities for Prevention

Reviews in Cardiovascular Medicine, 2012
Anemia is well recognized as a marker of poor prognosis in patients with cardiovascular disease. Despite increasing awareness that anemia is associated with higher mortality, more frequent hospitalization, and worse health status, it remains unclear whether treating chronic anemia improves patients' outcomes.
Adam C, Salisbury, Mikhail, Kosiborod
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Hospital-acquired infections and unvaccinated children due to chronic diseases: an investigation of the 2017–2019 measles outbreak in the northern region of Vietnam

BMC Infectious Diseases
Background Measles remains a major public health burden worldwide. Parents often hesitate to vaccinate children with chronic diseases. We investigated the association between the percentage of vaccination and chronic diseases and explore hospital ...
Dien M. Tran, Thinh Ong, Tung V. Cao, Quang Thai Pham, Hien Do, Phuc H. Phan, Marc Choisy, Nhung T. H. Pham   +7 more
doaj   +1 more source

Methicillin-resistant Staphylococcus aureus (MRSA) carriage in a dermatology unit

Clinics, 2011
OBJECTIVE: The aim of this study was to characterize Staphylococcus aureus (MRSA) carriage in a dermatology unit. METHODS: This was a prospective and descriptive study.
Renata L. Pacheco, Renata D. Lobo, Maura S. Oliveira, Elthon F. Farina, Cleide R. Santos, Silvia F. Costa, Maria Clara Padoveze, Cilmara P. Garcia, Priscila A. Trindade, Ligia M. Quitério, Evandro A. Rivitti, Elsa M. Mamizuka, Anna S. Levin   +12 more
doaj   +1 more source

Frequency and relevance of concomitant diseases in elderly patients hospitalized for community acquired pneumonia

Srpski arhiv za celokupno lekarstvo, 2009
Introduction. Patients' age and concomitant diseases are relevant for the development and treatment outcome of pneumonia. Objective. To establish the frequency and relevance of concomitant diseases in patients over 65 years of age hospitalized for community acquired pneumonia. Methods.
Đurić Mirna, Považan Đorđe, Sečen Nevena, Perin Branislav   +3 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. [PDF]

, 2007
BACKGROUND\ud \ud Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We
Schellenberg, David, Penelope Vountasou, Vountasou Penelope, Alonso Pedro L, Kahigwa, E., Schellenberg David, Aponte, John J., Clara Menendez, Marcel Tanner, Vountasou, Penelope, Hassan Mshinda, Mshinda Hassan, John J Aponte, Pedro L Alonso, Mshinda, Hassan, Tanner, Marcel, Aponte John J, Alonso, Pedro, Vountasou, P., David Schellenberg, Kahigwa, Elizeus, Elizeus Kahigwa, Aponte, John J, Menendez Clara, Tanner Marcel, Menendez, Clara, Alonso, Pedro L, Kahigwa Elizeus   +27 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Hospital acquired blood stream infection as an adverse outcome for patients admitted to hospital with other principle diagnosis

Saudi Journal of Anaesthesia, 2014
Background: Hospital acquired infections (HAI) have emerged as an important public health problem and are a leading cause of morbidity and mortality worldwide.
Hamdan H Al-Hazmi, Tariq Al-Zahrani, Ahmed M Elmalky   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source