Results 71 to 80 of about 568,795 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Point of care tests for hospital-acquired infections (HAIs) : economic analysis report [PDF]

A number of clinical/disease areas have been prioritised by the Technology Strategy Board (TSB) and Department of Health (DH) for the DIIA Innovation Platform.
Szczepura, Ala, Osipenko, Leeza
core  

Exons Analysis of Interferon-Gamma Receptor 1 Gene in Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in the Central Region of Iran

مجله دانشکده پزشکی اصفهان, 2019
Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare immunodeficiency disease which is caused by interferon-gamma (IFN-γ) signaling impairment.
Roya Sherkat, Majid Yaran, Nioosha Nekooei, Elaheh Talebi, Hamid Rahimi, Bahram Bagherpoor, Mahdieh Behnam, Soodabeh Rostami, Somayeh Najafi, Azita Nourimahdavi, Mazdak Ganjalikhani-Hakemi, Fariba Farid, Narges Rahmanian   +12 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Using ICD-10-AM codes to characterise hospital-acquired complications

, 2009
This paper describes the limitations of using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-IO-AM) to characterise patient harm in hospitals. Limitations were identified
Nghiem, Hong Son, Michel, Jude L., Jackson, Terri J., Michel, Jude L, Jackson, Terri J   +4 more
core   +1 more source

Surveillance and response systems for elimination of tropical diseases : summary of a thematic series in infectious diseases of poverty [PDF]

, 2016
The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with, and disseminate in an open-access format, science outside traditional disciplinary boundaries.
Zhou, Xiao-Nong, Xiao-Nong Zhou (92570), Yap, Peiling, Utzinger, Jürg, Robert Bergquist (377449), Xia Zhou (291729), Zhou, Xia, Bergquist, Robert, Peiling Yap (596280), Marcel Tanner (33894), JĂźrg Utzinger (3428396), Tanner, Marcel   +11 more
core   +1 more source

Clinical-epidemiological characteristics of patients with hospital acquired infections in a service of internal medicine from Santiago de Cuba

Medisan, 2022
Introduction: The cross or hospital infections constitute an important health problem in all the hospitals of the world. Objective: To describe the clinical and epidemiological characteristics of patients with hospital infections.
Liliet Arrate Lobaina, Carlos Enrique Morales Lobaina, Luis Ángel Cantillo Navarro, Juana Despaigne Bonne, Ivett Maria Heredia Leal   +4 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Analysis of risk factors for hospital-acquired pneumonia in schizophrenia

Frontiers in Psychiatry
BackgroundHospital-acquired pneumonia is one of the most important causes of recurrent illness, disease progression, and even death during hospitalization.
Yu-hang Chen, Cong-ying Ren, Yu Liao
doaj   +1 more source