Results 61 to 70 of about 5,605,502 (289)

Point of care tests for hospital-acquired infections (HAIs) : economic analysis report [PDF]

A number of clinical/disease areas have been prioritised by the Technology Strategy Board (TSB) and Department of Health (DH) for the DIIA Innovation Platform.
Szczepura, Ala, Osipenko, Leeza
core  

Exploring the impact of Chinese medicine on CD4 cell counts in people living with HIV by mixed-effects model: a retrospective cohort study based on propensity score matching

Frontiers in Immunology
BackgroundCD4 cells are the targets of human immunodeficiency virus (HIV). If left untreated, HIV enters CD4 cells and replicates, ultimately leading to the death of the infected cells. The loss of these cells impairs immune function. As Chinese medicine
Runyu Zhu, Runyu Zhu, Yantao Jin, Yantao Jin, Qiujia Kang, Yanmin Ma, Huangchao Jia, Jun Yuan, Xiuxia Ma, Lihua Chen, Ruohan Sun, Ruohan Sun, Zichen He, Zichen He, Siyu Wang, Siyu Wang, Juan Wang, Liran Xu, Huijun Guo, Qianlei Xu, Qianlei Xu, Qianlei Xu   +21 more
doaj   +1 more source

Approach to Hospital-Acquired and Methicillin-Resistant Staphylococcus aureus Meningitis [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2013
Among the hospital infections, hospital-acquired central nervous system infections are quite important due to the high mortality. The pathogens that cause hospital-acquired meningitis differ according to the immune system and underlying diseases.
Selin BARDAK ÖZCEM, Oğuz Reşat SİPAHİ   +1 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Application of agent-based simulation to the modelling and management of hospital-acquired infections [PDF]

Hospital-acquired infections (HAIs) are a big threat to the well-being of patients and place a heavy burden on hospital resources. The thesis provides the first attempt to apply agent-based simulation (ABS) to describe the transmission dynamics and ...
Meng, Yang
core  

Exons Analysis of Interferon-Gamma Receptor 1 Gene in Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in the Central Region of Iran

مجله دانشکده پزشکی اصفهان, 2019
Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare immunodeficiency disease which is caused by interferon-gamma (IFN-γ) signaling impairment.
Roya Sherkat, Majid Yaran, Nioosha Nekooei, Elaheh Talebi, Hamid Rahimi, Bahram Bagherpoor, Mahdieh Behnam, Soodabeh Rostami, Somayeh Najafi, Azita Nourimahdavi, Mazdak Ganjalikhani-Hakemi, Fariba Farid, Narges Rahmanian   +12 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Clinical-epidemiological characteristics of patients with hospital acquired infections in a service of internal medicine from Santiago de Cuba

Medisan, 2022
Introduction: The cross or hospital infections constitute an important health problem in all the hospitals of the world. Objective: To describe the clinical and epidemiological characteristics of patients with hospital infections.
Liliet Arrate Lobaina, Carlos Enrique Morales Lobaina, Luis Ángel Cantillo Navarro, Juana Despaigne Bonne, Ivett Maria Heredia Leal   +4 more
doaj  

SUMMARY OF LONG TERM EXPERIENCE IN ACQUIRED HEART DISEASES SURGERY

Вестник трансплантологии и искусственных органов, 2014
In this article we discuss the results of surgical treatment in patients with different acquired heart diseases. Procedures ranged from valve reconstruction, coronary artery revascularization, surgical repair or graft repair of the thoracic aorta to ...
M. L. Semenovsky, G. A. Akopov, G. V. Aniskevich, E. K. Mekhtiev, N. N. Tarabarko, D. A. Belokurov   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source