Results 81 to 90 of about 5,605,502 (289)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Frequency and relevance of concomitant diseases in elderly patients hospitalized for community acquired pneumonia

Srpski arhiv za celokupno lekarstvo, 2009
Introduction. Patients' age and concomitant diseases are relevant for the development and treatment outcome of pneumonia. Objective. To establish the frequency and relevance of concomitant diseases in patients over 65 years of age hospitalized for community acquired pneumonia. Methods.
Đurić Mirna, Považan Đorđe, Sečen Nevena, Perin Branislav   +3 more
openaire   +3 more sources

Modbury Hospital Exterior photo

, 1981
Black and white photo of the exterior of Modbury ...
Modbury Hospital
core   +1 more source

Hospital-acquired infections and unvaccinated children due to chronic diseases: an investigation of the 2017–2019 measles outbreak in the northern region of Vietnam

BMC Infectious Diseases
Background Measles remains a major public health burden worldwide. Parents often hesitate to vaccinate children with chronic diseases. We investigated the association between the percentage of vaccination and chronic diseases and explore hospital ...
Dien M. Tran, Thinh Ong, Tung V. Cao, Quang Thai Pham, Hien Do, Phuc H. Phan, Marc Choisy, Nhung T. H. Pham   +7 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Methicillin-resistant Staphylococcus aureus (MRSA) carriage in a dermatology unit

Clinics, 2011
OBJECTIVE: The aim of this study was to characterize Staphylococcus aureus (MRSA) carriage in a dermatology unit. METHODS: This was a prospective and descriptive study.
Renata L. Pacheco, Renata D. Lobo, Maura S. Oliveira, Elthon F. Farina, Cleide R. Santos, Silvia F. Costa, Maria Clara Padoveze, Cilmara P. Garcia, Priscila A. Trindade, Ligia M. Quitério, Evandro A. Rivitti, Elsa M. Mamizuka, Anna S. Levin   +12 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Modbury Hospital Site photos

, 1978
Black and white photos of the developments of Modbury Hospital in August ...
Modbury Hospital
core   +1 more source

Hospital acquired blood stream infection as an adverse outcome for patients admitted to hospital with other principle diagnosis

Saudi Journal of Anaesthesia, 2014
Background: Hospital acquired infections (HAI) have emerged as an important public health problem and are a leading cause of morbidity and mortality worldwide.
Hamdan H Al-Hazmi, Tariq Al-Zahrani, Ahmed M Elmalky   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source