Results 101 to 110 of about 568,795 (313)

Características das infecções em indivíduos portadores de neoplasias hematológicas internados no Hospital Universitário Professor Polydoro Ernani de São Thiago [PDF]

, 2014
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação Multidisciplinar em Saúde, Florianópolis, 2014.As neoplasias malignas do sistema hematopoiético atingem células ...
Almeida, Adriana Brejinski de
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The epidemiology, transmission dynamics and control of healthcare-associated infections [PDF]

This thesis presents research on the epidemiology and transmission dynamics of healthcare-associated infections (HCAI) and focuses on the antibiotic resistant hospital pathogen methicillin-resistant Staphylococcits aureus (MRSA).
Robotham, Julie
core  

Hospital-acquired bloodstream infections in critically ill cirrhotic patients: a post-hoc analysis of the EUROBACT-2 international cohort study. [PDF]

BACKGROUND Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are especially susceptible to infections, yet there is a knowledge gap in the epidemiological ...
Morris, Andrew Conway, Timsit, Jean François, Prazak, Josef, Wozniak, Hannah, Mikstacki, Adam, de Bus, Liesbet, Bassetti, Matteo, Conway Morris, Andrew, Akova, Murat, Arvaniti, Kostoula, Bracht, Hendrik, Timsit, Jean-François, Buetti, Niccolò, Leone, Marc, Barbier, François, https://orcid.org/, on behalf of the EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network, Alsisi, Adel, Loiodice, Ambre, Ruckly, Stéphane, EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network, Paiva, Jose Artur, Paiva, Jose, Artur, (EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and OUTCOMEREA Net, Tabah, Alexis, Valeanu, Liana, Ferrer, Ricard   +26 more
core   +1 more source

How Do Time Since Diagnosis and Sociodemographic Factors Influence Attitudes Towards HIV Status Disclosure in People Living with HIV in Poland? Data from Go Holistic Go Beyond Project

Viruses
The aim of this publication is to present the data from Polish respondents of the Go Holistic Go Beyond Project, which investigates social, professional and intimate relations of people living with HIV in Central and Eastern Europe.
Martyna Lara, Dominik Bursa, Błażej Rozpłochowski, Agata Waszczuk, Monika Bociąga-Jasik, Justyna D. Kowalska   +5 more
doaj   +1 more source

Cholesterol efflux responds to viral load and CD4 counts in HIV+ patients and is dampened in HIV exposed

Journal of Lipid Research, 2018
Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages
Olivia Tort, Tuixent Escribà, Lander Egaña-Gorroño, Elisa de Lazzari, Montserrat Cofan, Emma Fernandez, José Maria Gatell, Esteban Martinez, Felipe Garcia, Mireia Arnedo   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A study of the incubation period, or age at onset, of the transmissible spongiform encephalopathies/prion diseases. [PDF]

In order to model epidemics of infectious diseases, particularly to estimate probable numbers of cases with onset at any particular time, it is necessaiy to incorporate a term for the incubation period frequency distribution. Sartwell's hypothesis states
Wooldridge, Marion Joan Anstee
core   +1 more source

EPIDEMIOLOGY ASPECTS OF HOSPITAL-ACQUIRED INFECTION MORBIDITY IN HEALTH SURGERY HOSPITALS IN PRIMORSKY REGION

Инфекция и иммунитет, 2018
The problem of prophylaxis and treatment of the hospital-acquired infections caused remains actual and urgent and stubborn in modern medicine. Appearance of antimicrobial agents resistant and high virulent strains adapting also to desinfectants ...
A. V. Martynova, A. Yu. Gorkavaya, V. L. Abashina, L. M. Semeikina   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source