Results 101 to 110 of about 5,605,502 (289)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Risk of Noncommunicable Diseases After Hospitalization for Community-Acquired Pneumonia

Open Forum Infectious Diseases
Abstract Background Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. Increasing evidence suggests that CAP may contribute to long-term morbidity through the development of noncommunicable diseases (NCDs).
Julio Ramirez, Stephen Furmanek, Thomas Chandler, Rodrigo Cavallazzi, Anupama Raghuram   +4 more
openaire   +2 more sources

Disease spectrum of patients with hospital-acquired multidrug-resistant organism infections in the intensive care unit: a retrospective study

Frontiers in Microbiology
ObjectiveTo understand the infection status and disease spectrum distribution of patients with hospital-acquired Multidrug-resistant Organism (MDRO) Infections in an intensive care unit (ICU) before, during, and after the Coronavirus Disease 2019 (COVID ...
Xiaowu Wang, Yan Liu, Yunyun Ding, Mei Li, Yong Gao, Tuantuan Li   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Legionnaires' disease as a hospital‐acquired infection

International Journal of Clinical Practice, 1996
S, Manchanda, P J, Rees
openaire   +2 more sources

Modbury Hospital Foundation brochure

Brochure for the Modbury Hospital ...
Modbury Hospital
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

A Study on Antibiotic Related Resistance in UTI Patients: A Comparison Between Community Acquired and Hospital Acquired E. Coli

National Journal of Community Medicine, 2012
Background: UTI (urinary tract infection) is the most common among all hospital acquired infections world wide. In UTI, most common organism is E.coli.
Dharmishtha G Tada , Paragi J Gandhi , Kiran N Patel   +2 more
doaj  

Anxiety levels and physiological responses during top-rope and lead climbing: a cross-sectional study among sport climbers

BMC Sports Science, Medicine and Rehabilitation
Objectives Sport climbing presents an exceptionally interesting research field for issues related to anxiety and stress. This discipline, classified as an extreme sport, requires participants not only to be in very good physical condition, but also to be
Natalia Swinarska, Patrycja Krężel, Aleksandra Hapka, Anna Jurczak, Sylwia Wieder-Huszla   +4 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source