Results 121 to 130 of about 3,638,794 (367)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Implementation of Patient Safety in Hospitals Related to Patient Satisfaction in 2023

Media Keperawatan Indonesia
The incidence of non-injury incidents at Panembahan Senopati Hospital, Bantul is still the highest case every year, this is still several non-injury incident cases of 45.5% in 2022, this case is because there are still nurses or health workers who have ...
Apriliya Tiyas Ningrum, Imram Radne Rimba Putri, Raden Jaka Sarwadhamana   +2 more
doaj   +1 more source

Nosocomial Infection Prevention Through Universal Precaution in YOGYAKARTA Muhammadiyah Hospital [PDF]

, 2016
Prevention of nosocomial infections in hospitals can be done through the implementation of universal precaution program or action asepsis and antisepsis tapping. These actions undertaken by health workers, both nurses and physicians, universal precaution
Handayani, L. (Lina), Hastuti, S. K. (Siti), Marwati, T. (Triani), Munira, L. (Lafi), Solikhah, S. (Solikhah)   +4 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Survey-Based Studies of the Agility Construct in the Healthcare Sector: A Systematic Literature Review

Applied Sciences
As a dynamic capability, agility has been extensively examined within manufacturing settings due to the industry’s dynamics and the imperative for rapid adaptation to unforeseen market changes.
Jorge Flavio Sarmiento Falla, Waldemar Karwowski   +1 more
doaj   +1 more source

Hospitals and Urbanism in Rome, 1200-1500 [PDF]

, 2015
Carla Keyvanian
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Patients\' Satisfaction in Hospitals of Iran: A systematic Review and Meta-Analysis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Patients' satisfaction is one of the important indicators for measuring healthcare quality in hospitals. The present study was performed aiming at determining the level of patients' satisfaction in hospitals of Iran.   Methods:
Parvaneh Esfahani, Fahze Nezamdust
doaj  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source