Results 251 to 260 of about 803,197 (352)

Characterization of the role of putative <i>Aeromonas caviae</i>-specific virulence factor, <i>flgB,</i> in virulence and host-pathogen interactions. [PDF]

J Bacteriol
Hritzo BA, Michalski JM, Rasko DA.
europepmc   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities. [PDF]

Front Cell Infect Microbiol
Li J, Feng H, Chen D, Zhang H, Liao Y.
europepmc   +1 more source

Faculty Opinions recommendation of Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging.

, 2018
Frank Seeber, Martin Blume
openalex   +2 more sources

HLA-E: exploiting pathogen-host interactions for vaccine development [PDF]

, 2019
Hannah Sharpe, Georgina Bowyer, Simon Brackenridge, Teresa Lambe   +3 more
openalex   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Metabolomic profiling of host-pathogen interactions: differential effects of Gram-positive and Gram-negative bacterial secretomes on THP-1 macrophage metabolism. [PDF]

RSC Adv
Abuawad A, Romero M, Jarquin SM, Ghaemmaghami AM, Kim DH.   +4 more
europepmc   +1 more source

FROM ENVIRONMENTAL RESERVOIRS TO NEURAL DEVASTATION: A COMPREHENSIVE REVIEW ON THE BRAIN-EATING AMOEBA NAEGLERIA FOWLERI, ITS PATHOPHYSIOLOGY, HOST–PATHOGEN INTERACTIONS, AND THERAPEUTIC CHALLENGES

Yash Srivastav1, Shankar Gavaroji2, Tanmay Ghosh3, Deepika Singh4, Rohini Armo5, Vivek6, Harish Nath7, Swapnil Dattatray Darade8, Varaganti Sai Chitra Prathyusha*9
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Publisher Correction: Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Scientific Reports
Alyssa Schami, M. Nurul Islam, Matthew Wall, Amberlee Hicks, Reagan Meredith, Barry Kreiswirth, Barun Mathema, John T. Belisle, Jordi B. Torrelles   +8 more
doaj   +1 more source