Results 101 to 110 of about 3,640,353 (386)

Description of a new Crossidius LeConte (Coleoptera: Cerambycidae: Cerambycinae: Trachyderini) from southern Georgia with comments on its biology and unusual distribution [PDF]

, 2013
Crossidius grahami Morris and Wappes new species (Coleoptera: Cerambycidae) is described from the Ohoopee Dunes of southern Georgia. Comments are included on the new species’ biology and disjunct distribution compared to other species of Crossidius ...
Morris, Roy F., Wappes, James E.
core  

Candidalysin biology and activation of host cells

mBio
ABSTRACT Candida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal, Claire M. Lyon, Jakob L. Sprague, Johannes Sonnberger, Olivia K. A. Paulin, Don N. Wickramasinghe, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik   +8 more
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Systems Biology Approaches for Host–Fungal Interactions: An Expanding Multi-Omics Frontier

Omics, 2016
Opportunistic fungal infections are an increasing threat for global health, and for immunocompromised patients in particular. These infections are characterized by interaction between fungal pathogen and host cells. The exact mechanisms and the attendant
Luka Culibrk, Carys A. Croft, S. Tebbutt
semanticscholar   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Carbajo-Lozoya, Javier, Dall'Armi, Ekatarina von, Ditt, Vanessa, Drosten, Christian, Friedel, Caroline C., Haas, Juergen G., Herrler, Georg, Herzog, Petra, Hilgenfeld, Rolf, Kallies, Stefan, Kuri, Thomas, Kögl, Manfred, Müller, Marcel A., Niemeyer, Daniela, Pfefferle, Susanne, Pumpor, Ksenia, Pöhlmann, Stefan, Schwarz, Frank, Schwegmann-Wessels, Christel, Schöpf, Julia, Steffen, Imke, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Thiel, Volker, Weber, Friedemann, Zimmer, Ralf, Züst, Roland   +27 more
core   +1 more source

A system biology perspective on environment–host–microbe interactions [PDF]

Human Molecular Genetics, 2018
A vast, complex and dynamic consortium of microorganisms known as the gut microbiome colonizes the human gut. Over the past few decades, we have developed an increased awareness of its important role in human health. In this review we discuss the role of the gut microbiome in complex diseases and the possible causal scenarios behind its interactions ...
Alexandra Zhernakova, Lianmin Chen, Sanzhima Garmaeva, Jingyuan Fu, Cisca Wijmenga, Cisca Wijmenga   +5 more
openaire   +3 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A review on computational systems biology of pathogen–host interactions

Frontiers in Microbiology, 2015
Pathogens manipulate the cellular mechanisms of host organisms via pathogen–host interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to infections.
Saliha Durmuş, Tunahan Çakır, Arzucan Özgür, R. Guthke   +3 more
semanticscholar   +1 more source

Use of sigma factor M from Bacillus subtilis in the development of an orthogonal expression system in Escherichia coli [PDF]

, 2014
Background: Technological advances in synthetic biology, systems biology, and metabolic engineering have boosted applications of industrial biotechnology for an increasing number of complex and high added-value molecules.
Bervoets, Indra, Charlier, Daniel, De Mey, Marjan   +2 more
core  

Coevolution Maintains Diversity in the Stochastic "Kill the Winner" Model

, 2017
The "Kill the Winner" hypothesis is an attempt to address the problem of diversity in biology. It argues that host-specific predators control the population of each prey, preventing a winner from emerging and thus maintaining the coexistence of all ...
Goldenfeld, Nigel, Xue, Chi
core   +1 more source