Results 111 to 120 of about 6,290,609 (322)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Arbuscular mycorrhizal community composition associated with two plant species in a grassland ecosystem [PDF]

, 2002
Arbuscular mycorrhizal (AM) fungi are biotrophic symbionts colonizing about two-thirds of land plant species and found in all ecosystems. They are of major importance in plant nutrient supply and their diversity is suggested to be an important ...
Daniell, T.J., Duck, J.M., Fitter, A.H., Husband, R., Vandenkoornhuyse, P., Watson, I.J., Young, J.P.W.   +6 more
core   +1 more source

Host Plants of Spodoptera frugiperda (Lepidoptera: Noctuidae) in the Americas

African Entomology, 2018
The fall armyworm, Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae), is the most important noctuid pest in the Americas and has recently become an invasive pest in Africa. A detailed record of S.
D. Montezano, A. Specht, D. Sosa‐Gómez, V. F. Roque-Specht, J. C. Sousa-Silva, S. Paula-Moraes, Julie A Peterson, T. Hunt   +7 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Draft genome sequence of Pseudomonas moraviensis R28-S [PDF]

, 2014
We report the draft genome sequence of Pseudomonas moraviensis R28-S, isolated from the municipal wastewater treatment plant of Moscow, ID. The strain carries a native mercury resistance plasmid, poorly maintains introduced IncP-1 antibiotic resistance ...
De Gelder, Leen, De Vos, Paul, Hughes, Julie, Hunter, Samual S, Loftie-Eaton, Wesley, Settles, Matthew L, Stragier, Pieter, Top, Eva M, Yano, Hirukazo   +8 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Aquilaria malaccensis (Malvales: Thymelaeaceae): a new host plant record for Deudorix epijarbas cinnabarus (Lepidoptera: Lycaenidae) in Malaysia

Journal of Threatened Taxa, 2019
Aquilaria malaccensis Lam., a highly threatened and one of the most sought-after agarwood producing species listed in the Appendix II of CITES, is reported here as the new host plant for Deudorix epijarbas cinnabarus in Malaysia.
Kah Hoo Lau, Su Ping Ong
doaj   +1 more source

\u3ci\u3eAgonopterix Alstroemeriana\u3c/i\u3e (Oecophoridae) and Other Lepidopteran Associates of Poison Hemlock \u3ci\u3e(Conium Maculatum)\u3c/i\u3e in East Central Illinois [PDF]

, 2017
Poison hemlock (Conium maculatum) (Apiaceae), a noxious Eurasian weed extensively naturalized throughout North America, is characteristically attacked by few insects.
Berenbaum, May R, Harrison, Terry L
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Leptinotarsa decemlineata (Coleoptera: Chrysomelidae) Observed Feeding on Chamaesaracha sp. in Eastern Colorado. [PDF]

, 2018
Egg, larval, and adult life stages of Colorado potato beetle, Leptinotarsa decemlineata (Say), were observed feeding on or attached to a previously undocumented host plant belonging to the genus Chamaesaracha in eastern Colorado on July 2017. At one site,
Cohen, Zachary, Crossley, Michael S, Pélissié, Benjamin, Schoville, Sean D   +3 more
core   +2 more sources