Results 121 to 130 of about 6,173,627 (355)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]

, 2015
Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Kulagina, Natalja, Huitema, Edgar; id_orcid, Motion, Graham B., Marques Monteiro Amaro, Tiago M.   +3 more
core   +1 more source

Aquilaria malaccensis (Malvales: Thymelaeaceae): a new host plant record for Deudorix epijarbas cinnabarus (Lepidoptera: Lycaenidae) in Malaysia

Journal of Threatened Taxa, 2019
Aquilaria malaccensis Lam., a highly threatened and one of the most sought-after agarwood producing species listed in the Appendix II of CITES, is reported here as the new host plant for Deudorix epijarbas cinnabarus in Malaysia.
Kah Hoo Lau, Su Ping Ong
doaj   +1 more source

Host Plants of Spodoptera frugiperda (Lepidoptera: Noctuidae) in the Americas

African Entomology, 2018
The fall armyworm, Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae), is the most important noctuid pest in the Americas and has recently become an invasive pest in Africa. A detailed record of S.
D. Montezano, A. Specht, D. Sosa‐Gómez, V. F. Roque-Specht, J. C. Sousa-Silva, S. Paula-Moraes, Julie A Peterson, T. Hunt   +7 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cochin China atalantia (Atalantia citroides) as a new alternative host of the bacterium causing citrus Huanglongbing [PDF]

, 2015
Through graft inoculation and psyllid transmission experiments, the Cochin China atalantia (Atalantia citroides) was found to be a new alternative host of the fastidious bacterium (Candidatus Liberibacter asiaticus = Las) causing citrus Huanglongbing ...
S. Vung, H. J. Su, T. H. Hung, C. H. Tsai, Y. C. Feng   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The transcriptome of Nacobbus aberrans reveals insights into the evolution of sedentary endoparasitism in plant-parasitic nematodes [PDF]

, 2014
This work was supported by the Biotechnology and Biological Sciences Research Council and The James Hutton Institute (JHI). The James Hutton Institute receives funding from the Scottish Government.
Jones, John T., Cock, Peter J. A., Urwin, P.E., Eves-van den Akker, Sebastian, Cock, P.J.A., Danchin, Etienne, Danchin, Etienne G. J., Lilley, Catherine J., Urwin, Peter E., Jones, J.T., Lilley, C.J., Eves-van den Akker, S, Rancurel, Corinne   +12 more
core   +1 more source

An illustrated checklist of the tribe Nomophilini (Lepidoptera: Spilomelinae) with a newly recorded genus in Korea

Journal of Asia-Pacific Biodiversity
The current knowledge of the tribe Nomophilini in Korea is reported, based on several taxa described to date. In addition, we report Syngamia falsidicalis (Walker, 1859) and the genus Syngamia Guenée (1854) for the first time in Korea.
Tak-Gi Lee, Jae-Ho Ko, Hanul Kim, Neung-Ho Ahn, Jongwoo Jung, Yang-Seop Bae   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source