Results 61 to 70 of about 5,613,148 (257)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

At the frontier; RXLR effectors crossing the Phytophthora -host interface [PDF]

, 2011
Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and ...
Meijer, H.J.G., Francine eGovers, Govers, F., Bouwmeester, K., Klaas eBouwmeester, Harold J. G. Meijer, Francine Govers, Harold. J.G. eMeijer, Klaas Bouwmeester   +8 more
core   +1 more source

Plant immunity in plant-aphid interactions

Frontiers in Plant Science, 2014
Aphids are economically important pests that cause extensive feeding damage and transmit viruses. While some species have a broad host range and cause damage to a variety of crops, others are restricted to only closely related plant species.
Maelle eJaouannet, Patricia eRodriguez, Peter eThorpe, Camille eLenoir, Camille eLenoir, Ruari eMacLeod, Ruari eMacLeod, Carmen eEscudero-Martinez, Carmen eEscudero-Martinez, Jorunn eBos, Jorunn eBos   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tomato resistance to Alternaria stem canker: localization in host genotypes and functional expression compared to non-host resistance [PDF]

, 1989
The Alternaria stem canker resistance locus (Asc-locus), involved in resistance to the fungal pathogen Alternaria alternata f. sp. lycopersici and in insensitivity to host-specific toxins (AAL-toxins) produced by the pathogen, was genetically mapped on ...
Witsenboer, H.M.A.,, Griend, E.G. van de,, Witsenboer, H.M.A., Griend, E.G. van de, Hille, J., Tiersma, J.B., Nijkamp, H.J.J., Tiersma, J.B.,, Nijkamp, H.J.J.,, Hille, J.,   +9 more
core   +2 more sources

SlCNGC1 and SlCNGC14 Suppress Xanthomonas oryzae pv. oryzicola-Induced Hypersensitive Response and Non-host Resistance in Tomato

Frontiers in Plant Science, 2018
Mechanisms underlying plant non-host resistance to Xanthomonas oryzae pv. oryzicola (Xoc), the pathogen causing rice leaf streak disease, are largely unknown.
Xuan-Rui Zhang, You-Ping Xu, Xin-Zhong Cai   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evolution of linked avirulence effectors in Leptosphaeria maculans is affected by genomic environment and exposure to resistance genes in host plants [PDF]

, 2010
Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are complementary to pathogen avirulence (Avr) genes.
McDonald, B., Patrick C Brunner, Anton J Cozijnsen, Barbara J. Howlett, Cozijnsen, Anton J., Brunner, PC, van de Wouw, A.P., Howlett, B.J., Brunner, P., Howlett, BJ, Brunner Patrick C., McDonald, BA, James K. Hane, Oliver, R.P., Angela P Van de Wouw, Richard P. Oliver, Hane, James K., Howlett, Barbara J., Brunner, Patrick C., Oliver, Richard P., Richard P Oliver, Bruce A. McDonald, Angela P. Van de Wouw, Hane, JK, Oliver Richard P., Bruce A McDonald, Anton J. Cozijnsen, Brunner, P.C., Cozijnsen, AJ, Howlett, B., Hane, J., Hane James K., Hane, J.K., Barbara J Howlett, McDonald, Bruce A., van de Wouw, AP, Cozijnsen, A., James K Hane, Cozijnsen Anton J., Howlett Barbara J., McDonald Bruce A., Oliver, Richard, McDonald, B.A., Van de Wouw Angela P., Van de Wouw, Angela P., Patrick C. Brunner, Cozijnsen, A.J., Van de Wouw, A., Oliver, RP   +48 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Host Plant Resistance to Insects in Vegetable Crops

Host plant resistance is an effective approach to manage insect pests in vegetable crops. This approach involves the use of plant traits that deter or reduce insect feeding and reproduction involving the mechanisms of antibiosis, antixenosis, and ...
Kumaraswamy, Sunil, Nasif, Saifullah Omar, Siddique, Abu Bakar, Chowdary, Rajesh, Chaitanya, Alamuru Krishna, Karuppannasamy, Ashok, Mohan, Muthugounder   +6 more
core   +1 more source